Tris(2-hydroxyethyl) 2-hydroxypropane-1,2,3-tricarboxylate | 86714-13-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tris(2-hydroxyethyl) 2-hydroxypropane-1,2,3-tricarboxylate
• CAS: 86714-13-8
• 化学式: C₁₂H₂₀O₁₀
• 分子量: 324.285
• InChiKey: XHDRYKHQTDSTRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  160
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  柠檬酸三乙酯 、 乙二醇 在 三氟化硼乙醚 作用下， 反应 26.0h， 生成 Tris(2-hydroxyethyl) 2-hydroxypropane-1,2,3-tricarboxylate
  参考文献：
  名称：

  [EN] BIOBASED POLYOL CROSS-LINKERS FOR USE IN PREPARING POLYESTERS AND REVERSIBLE POLYURETHANES
  [FR] AGENTS DE RÉTICULATION DE POLYOLS BIOSOURCÉS DESTINÉS À ÊTRE UTILISÉS DANS LA PRÉPARATION DE POLYESTERS ET DE POLYURÉTHANES PAR RÉACTION RÉVERSIBLE

  摘要：

  公开号：

  WO2011041476A3

文献信息

• Shape-retentive hydrogel particle aggregates and their uses
  申请人：——

  公开号：US20040086548A1

  公开（公告）日：2004-05-06

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及具有以下特征的水凝胶颗粒和聚集体，包括但不限于保持形状、具有弹性、可控的孔径大小和可控的降解速率，使它们适用于广泛的应用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• SHAPE-RETENTIVE HYDROGEL PARTICLE AGGREGATES AND THEIR USES
  申请人：St. John John V.

  公开号：US20080166409A1

  公开（公告）日：2008-07-10

  The present invention is related to hydrogel particles and aggregates formed therefrom having characteristics including, without limitation, shape-retentiveness, elasticity, controllable pore sizes and controllable degradation rates that render them useful for a wide variety of applications including, without limitation, the controlled release of biologically active substances, in vivo medical devices, tissue growth scaffolding and tissue replacement.

  本发明涉及水凝胶颗粒及由其形成的聚集体，其特征包括但不限于形状保持性、弹性、可控孔径和可控降解速率，使它们在各种应用中有用，包括但不限于生物活性物质的控制释放、体内医疗器械、组织生长支架和组织替代。
• HYDROGEL WOUND DRESSING AND BIOMATERIALS FORMED IN SITU AND THEIR USES
  申请人：St. John John

  公开号：US20110123621A1

  公开（公告）日：2011-05-26

  The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

  本发明涉及一种形成保持形状和适应形状的聚集伤口敷料和生物材料的方法，其由凝胶纳米粒子和伤口或体液组成，这些聚集体由非共价键物理力保持在一起，例如，但不限于疏水-亲水相互作用和氢键。该方法包括将凝胶纳米粒子的干粉引入伤口部位，其中纳米粒子吸收一些血液或伤口渗出物，并在现场凝聚成所述的保持形状的聚集敷料。该方法还包括将干纳米粒子粉末引入或涂覆于体内湿润的组织中，以形成所述的保持形状的生物材料。此外，该方法还包括将生物医学剂合并进来，以生产用于各种医疗应用的医用聚集敷料或生物材料。本发明还涉及使用凝胶纳米粒子形成保持形状的聚集体的方法。
• Method of formation of shape-retentive aggregates of gel particles and their uses
  申请人：Moro G. Daniel

  公开号：US20050118270A1

  公开（公告）日：2005-06-02

  The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.

  本发明涉及一种形成凝胶粒子形状保持性聚集体的方法，其中聚集体通过非共价键物理力（如但不限于疏水-亲水相互作用和氢键）保持在一起。该方法包括将极性液体中的凝胶微粒悬浮液以选定的浓度（其中凝胶微粒具有绝对zeta电位）引入介质中，在介质中凝胶微粒的绝对zeta电位降低，从而使凝胶微粒凝聚成所要求的保形聚集体。本发明还涉及凝胶颗粒形状保持聚集体形成方法的用途。
• EP1567132A4
  申请人：——

  公开号：EP1567132A4

  公开（公告）日：2007-03-21