1-chloro-9-methoxy-11-methyl-6H-indolo[2,3-b][1,6]naphthyridine | 938052-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-chloro-9-methoxy-11-methyl-6H-indolo[2,3-b][1,6]naphthyridine
• CAS: 938052-38-1
• 化学式: C₁₆H₁₂ClN₃O
• 分子量: 297.744
• InChiKey: VSDYYUSIDDNBEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  50.8
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-chloro-9-methoxy-11-methyl-6H-indolo[2,3-b][1,6]naphthyridine 以 二氯甲烷 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  Synthesis and biological activity of 5-aza-ellipticine derivatives

  摘要：

  Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase 11 and possible anti-tumor agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.093
• 作为产物：
  描述：

  4-methoxy-2-(prop-1-yn-1-yl)aniline 在 TEA 作用下， 以 甲苯 、 苯 为溶剂， 反应 13.5h， 生成 1-chloro-9-methoxy-11-methyl-6H-indolo[2,3-b][1,6]naphthyridine
  参考文献：
  名称：

  Synthesis and biological activity of 5-aza-ellipticine derivatives

  摘要：

  Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase 11 and possible anti-tumor agents. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.09.093

文献信息

• Synthesis and biological activity of 5-aza-ellipticine derivatives
  作者：Deborah L. Moody、Marcin Dyba、Teresa Kosakowska-Cholody、Nadya I. Tarasova、Christopher J. Michejda

  DOI：10.1016/j.bmcl.2006.09.093

  日期：2007.4

  Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase 11 and possible anti-tumor agents. (c) 2006 Elsevier Ltd. All rights reserved.