2-(4-Iodophenoxy)-pentadecane | 156575-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-Iodophenoxy)-pentadecane
• 英文别名: 2-(4-iodophenoxy)pentadecane；1-iodo-4-pentadecan-2-yloxybenzene
• CAS: 156575-19-8
• 化学式: C₂₁H₃₅IO
• 分子量: 430.413
• InChiKey: FGZPFFOXFLTSSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-五癸醇 、 4-碘苯酚 、 甲基磺酰氯 、 2-(methylsulfonyloxy)pentadecane 在 potassium carbonate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(4-Iodophenoxy)-pentadecane
  参考文献：
  名称：

  Compositions of iodophenoxy alkanes and iodophenyl ethers in

  摘要：

  揭示了用于口服或逆行检查消化道的X射线造影剂组合物，包括能够在消化道上形成涂层的聚合物材料和具有以下结构的X射线产生剂的方法：##STR1##以及它们在消化道诊断放射学中的使用方法，其中Z=H，卤素，C.sub.1-C.sub.20烷基，环烷基，较低烷氧基，氰基，其中烷基和环烷基基团可被卤素或卤素较低烷基基团取代；R=C.sub.1-C.sub.25烷基，环烷基，或卤素较低烷基，可选择地被卤素，氟代较低烷基，芳基，较低烷氧基，羟基，羧基，较低烷氧基羰基或较低烷氧羰氧基，(CR.sub.1 R.sub.2).sub.p--(CR.sub.3.dbd.CR.sub.4).sub.m Q，或(CR.sub.1 R.sub.2).sub.p--C.tbd.C--Q；R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地为较低烷基，可选择地被卤素取代；x为1-4；n为1-5；m为1-15；p为1-10；Q为H，较低烷基，较低烯基，较低炔基，较低烷基烯，芳基，或芳基-较低烷基，位于药学上可接受的载体中。

  公开号：

  US05326553A1

文献信息

• Compositions of iodophenoxy alkanes and iodophenyl ethers and
  申请人：Sterling Winthrop Inc.

  公开号：US05531979A1

  公开（公告）日：1996-07-02

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

  揭示了用于口服或逆行检查消化道的X射线造影剂组合物，包括碘苯氧烷和碘苯醚作为X射线产生剂，与药学上可接受的粘土结合在药学上可接受的载体中；以及它们在消化道诊断放射学中的使用方法。
• Compositions of iodophenoxy alkanes and iodophenyl ethers in combination
  申请人：Sterling Winthrop Inc.

  公开号：US05607660A1

  公开（公告）日：1997-03-04

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodophenoxy alkane, iodophenyl alkenylalkyl ether or an iodophenyl alkynylalkyl ether x-ray producing agent in combination with a cellulose derivative in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.

  揭示了用于口服或逆行检查消化道的X射线造影剂，包括碘苯氧烷、碘苯烯基烷基醚或碘苯炔基烷基醚X射线造影剂，与纤维素衍生物结合在药学上可接受的载体中；以及它们在消化道诊断放射学中的使用方法。
• Compositions of iodophenoxy alkanes and iodophenyl ethers for
  申请人：Sterling Winthrop Inc.

  公开号：US05620677A1

  公开（公告）日：1997-04-15

  Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

  本发明涉及一种公式为##STR1##的对比剂，其包含在水性组合物中，并且用于诊断放射学中的胃肠道的方法，其中Z=H，卤素，C.sub.1-C.sub.20烷基，环烷基，较低的烷氧基，氰基，其中烷基和环烷基可以被卤素或卤素较低烷基置换；R=C.sub.1-C.sub.25烷基，环烷基或卤素较低烷基，可选择地被卤素，氟较低烷基，芳基，较低烷氧基，羟基，羧基，较低烷氧基羰基或较低烷氧基羰基氧基置换，(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q，或(CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地是较低烷基，可选择地被卤素置换；x为1-4；n为1-5；m为1-15；p为1-10；Q为H，较低烷基，较低烯基，较低炔基，较低烷基烯，芳基或芳基较低烷基。
• Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract
  申请人：NYCOMED IMAGING AS

  公开号：EP0609586A2

  公开（公告）日：1994-08-10

  Disclosed are contrast agents of the formula or pharmaceuticaoly acceptable salts thereof, contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z =H, halo, C₁-C₂₀ alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R =C₁-C₂₅ alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR₁R₂)p - (CR₃ = CR₄)mQ, or (CR₁R₂)p - C ≡ C - Q; R₁, R₂, R₃ and R₄ areindependently lower-alkyl, optionally substituted with halo; x is1-4; n is1-5; m is1-15; p is1-10; and Q isH, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.

  公开了式中的造影剂 或其药学上可接受的盐、 水性组合物中的造影剂及其在胃肠道放射诊断中的使用方法，其中 Z =H、卤素、C₁-C₂₀ 烷基、环烷基、低级烷氧基、氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代； R =C₁-C₂₅烷基、环烷基或卤代低烷基，可选择被卤代、氟代低烷基、芳基、低级烷氧基取代、羟基、羧基、低级烷氧基羰基或低级烷氧基羰氧基、(CR₁R₂)p - (CR₃ = CR₄)mQ 或 (CR₁R₂)p - C ≡ C - Q； R₁、R₂、R₃ 和 R₄ 独立为低级烷基，可选被卤代取代； x 为 1-4 n 是 1-5 m 是 1-15； P 是 1-10；以及 Q 是H、低级烷基、低级烯基、低级炔基、低级亚烷基、芳基或芳基-低级烷基。
• Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
  申请人：NYCOMED IMAGING AS

  公开号：EP0609587A2

  公开（公告）日：1994-08-10

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula or a pharmaceutically acceptable salt thereof, and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy lower-alkoxycarbonyl or lower-alkoxy-carbonyloxy, (CR1R2)p-CR3 =CR4)mQ, or (CR, R2)p-C=C-Q; Ri, R2, R3 and R4 are independently lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl in a pharmaceutically acceptable carrier.

  本发明公开了用于胃肠道口腔或逆行检查的 X 射线造影剂组合物，该组合物由一种可在胃肠道上形成涂层的聚合材料和一种 X 射线产生剂组成。 式的 X 射线产生剂 或其药学上可接受的盐、 及其在胃肠道放射诊断中的使用方法，其中 Z = H、卤素、C1-C20 烷基、环烷基、低级烷氧基、氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代； R = C1-C25 烷基、环烷基或卤代低烷基，可任选被卤、氟代低烷基、芳基、低烷氧基、羟基、低烷氧基羰基或低烷氧基羰氧基、(CR1R2)p-CR3 =CR4)mQ 或 (CR、R2)p-C=C-Q 取代； Ri、R2、R3 和 R4 独立为低级烷基，可选被卤代取代； x 为 1-4 n 是 1-5 m 是 1-15； p 是 1-10；以及 Q 是 H、低级烷基、低级烯基、低级炔基、低级亚烷基、芳基或芳基-低级烷基 在药学上可接受的载体中。