7,8-dihydroxy-4-methyl-3-propylcoumarin | 1658-72-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7,8-dihydroxy-4-methyl-3-propylcoumarin
• 英文别名: 7,8-Dihydroxy-4-methyl-3-propylchromen-2-one
• CAS: 1658-72-6
• 化学式: C₁₃H₁₄O₄
• 分子量: 234.252
• InChiKey: WZKJRVNNQYWDIW-UHFFFAOYSA-N

物化性质

• 熔点：
  190 °C (decomp)
• 沸点：
  431.0±45.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7,8-dihydroxy-4-methyl-3-propylcoumarin 、 乙酸酐 在 4-二甲氨基吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以78%的产率得到7,8-diacetoxy-4-methyl-3-propylcoumarin
  参考文献：
  名称：

  Calreticulin transacetylase: A novel enzyme-mediated protein acetylation by acetoxy derivatives of 3-alkyl-4-methylcoumarins

  摘要：

  Our earlier investigations culminated in the discovery of a unique membrane-bound enzyme Calreticulin transacetylase (CRTAase) in mammalian cells catalyzing the transfer of acetyl group from polyphenolic acetates (PAs) to certain functional proteins viz. Glutathione S-transferase (GST), NADPH Cytochrome c reductase and Nitric oxide synthase (NOS) resulting in the modulation of their biological activities. In order to develop SAR study, herein, we studied the influence of alkyl group at C-3 position of acetoxy coumarins on the CRTAase activity. The alkylated acetoxy coumarins lead to inhibition of catalytic activity of GST, and ADP induced platelet aggregation by the way of activation of platelet Nitric oxide synthase (NOS). Furthermore, the increase in size of the coumarin C-3 alkyl group was found to decrease the CRTAase activity. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2011.10.005
• 作为产物：
  描述：

  邻苯三酚 、 2-丙基乙酰乙酸乙酯 在 硫酸 作用下， 以78%的产率得到7,8-dihydroxy-4-methyl-3-propylcoumarin
  参考文献：
  名称：

  Calreticulin transacetylase: A novel enzyme-mediated protein acetylation by acetoxy derivatives of 3-alkyl-4-methylcoumarins

  摘要：

  Our earlier investigations culminated in the discovery of a unique membrane-bound enzyme Calreticulin transacetylase (CRTAase) in mammalian cells catalyzing the transfer of acetyl group from polyphenolic acetates (PAs) to certain functional proteins viz. Glutathione S-transferase (GST), NADPH Cytochrome c reductase and Nitric oxide synthase (NOS) resulting in the modulation of their biological activities. In order to develop SAR study, herein, we studied the influence of alkyl group at C-3 position of acetoxy coumarins on the CRTAase activity. The alkylated acetoxy coumarins lead to inhibition of catalytic activity of GST, and ADP induced platelet aggregation by the way of activation of platelet Nitric oxide synthase (NOS). Furthermore, the increase in size of the coumarin C-3 alkyl group was found to decrease the CRTAase activity. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2011.10.005

文献信息

• MALIK, O. P.;GUPTA, B. B.;ABROL, VEENA (MRS. ), INDIAN J. PHARM. SCI., 49,(1987) N 2, 71-75
  作者：MALIK, O. P.、GUPTA, B. B.、ABROL, VEENA (MRS. )

  DOI：——

  日期：——
• Calreticulin transacetylase: A novel enzyme-mediated protein acetylation by acetoxy derivatives of 3-alkyl-4-methylcoumarins
  作者：Sarah Jalal、Karam Chand、Abha Kathuria、Prabhjot Singh、Nivedita Priya、Bhavna Gupta、Hanumantharao G. Raj、Sunil K. Sharma

  DOI：10.1016/j.bioorg.2011.10.005

  日期：2012.2

  Our earlier investigations culminated in the discovery of a unique membrane-bound enzyme Calreticulin transacetylase (CRTAase) in mammalian cells catalyzing the transfer of acetyl group from polyphenolic acetates (PAs) to certain functional proteins viz. Glutathione S-transferase (GST), NADPH Cytochrome c reductase and Nitric oxide synthase (NOS) resulting in the modulation of their biological activities. In order to develop SAR study, herein, we studied the influence of alkyl group at C-3 position of acetoxy coumarins on the CRTAase activity. The alkylated acetoxy coumarins lead to inhibition of catalytic activity of GST, and ADP induced platelet aggregation by the way of activation of platelet Nitric oxide synthase (NOS). Furthermore, the increase in size of the coumarin C-3 alkyl group was found to decrease the CRTAase activity. (C) 2011 Elsevier Inc. All rights reserved.