2-(苯基甲氧基)-4-吡啶羧酸 | 467236-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(苯基甲氧基)-4-吡啶羧酸
• 中文别名: 2-(苯甲氧基)-4-吡啶羧酸
• 英文名称: 2-(phenylmethoxy)-4-pyridinecarboxylic acid
• 英文别名: 2-(benzyloxy)isonicotinic acid；2-benzyloxy-isonicotinic acid；2-phenylmethoxypyridine-4-carboxylic acid
• CAS: 467236-25-5
• 化学式: C₁₃H₁₁NO₃
• mdl: MFCD11100038
• 分子量: 229.235
• InChiKey: JIVIAPHYBVSLIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-(苯基甲氧基)-4-吡啶羧酸 、 碘甲烷 在 potassium hydrogencarbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 7.0h， 生成 methyl 2-(benzyloxy)isonicotinate
  参考文献：
  名称：

  EP1375484

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氯异烟酸 、 苯甲醇 在 potassium tert-butylate 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 6.0h， 生成 2-(苯基甲氧基)-4-吡啶羧酸
  参考文献：
  名称：

  GLUCOCORTICOID RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及以下式I的化合物 其中A，n，R1a至R1e和R2至R5如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物是糖皮质激素受体拮抗剂，可用于治疗和/或预防疾病，如糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺失调或抑郁症。

  公开号：

  US20090088425A1

文献信息

• Novel imidazole derivatives
  申请人：Aebi Johannes

  公开号：US20090012063A1

  公开（公告）日：2009-01-08

  The invention is concerned with novel imidazole derivatives of formula (I), wherein m, E, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

  这项发明涉及公式（I）的新型咪唑衍生物， 其中 m，E，R1，R2，R3，R4，R5，R6和R7如描述和索赔中所定义，并且其生理上可接受的盐。这些化合物是CCR-2受体、CCR-5受体和/或CCR-3受体的拮抗剂，可用作药物。
• Carboxylic acids
  申请人：——

  公开号：US20040116708A1

  公开（公告）日：2004-06-17

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. 1 In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): 2 (wherein Z represents a group represented by the formula (IV): 3 (wherein R 9 , R 10 , R 11 and R 12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C 1-6 alkyl group or a C 1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种新的羧酸衍生物，其盐或水合物可用作胰岛素增敏剂，并提供了一种以该衍生物为有效成分的药物。更具体地，本发明提供了一种由式(I)表示的羧酸化合物，其盐或水合物。在式中，Ar表示一个有6至14个成员的芳香环基团，该基团可以具有至少一个取代基；R1，R2，R3，R4，R5，R6，R7和R8相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基；X表示氧原子或亚甲基；Y表示由式(II)或(III)表示的基团：其中Z表示由式(IV)表示的基团：其中R9，R10，R11和R12相同或不同，每个表示氢原子，卤素原子，羟基，C1-6烷基或C1-6烷氧基）；m为0或1；n为0或1。
• Glucocorticoid receptor antagonists
  申请人：Hoffmann-La Roche Inc.

  公开号：US08143280B2

  公开（公告）日：2012-03-27

  The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

  本发明涉及公式I的化合物，其中A，n，R1a到R1e和R2到R5如说明书和权利要求中所定义的，并且它们的药学上可接受的盐。这些化合物是糖皮质激素受体拮抗剂，可用于治疗和/或预防疾病，如糖尿病，血脂异常，肥胖症，高血压，心血管疾病，肾上腺失衡或抑郁症。
• Imidazole derivatives
  申请人：Hoffman-La Roche Inc.

  公开号：US07935707B2

  公开（公告）日：2011-05-03

  The invention is concerned with novel imidazole derivatives of formula (I), wherein m, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

  本发明涉及式（I）的新型咪唑衍生物，其中m、E、R1、R2、R3、R4、R5、R6和R7如说明书和权利要求中所定义，以及其生理上可接受的盐。这些化合物是CCR-2受体、CCR-5受体和/或CCR-3受体的拮抗剂，可用作药物。
• CARBOXYLIC ACIDS
  申请人：Eisai Co., Ltd.

  公开号：EP1375484A1

  公开（公告）日：2004-01-02

  The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R9, R10, R11 and R12 are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.

  本发明提供了一种可用作胰岛素增敏剂的新型羧酸衍生物、其盐或其水合物，以及以该衍生物为有效成分的药物。更具体地说，它提供了一种由式（I）代表的羧酸化合物、其盐或它们的水合物。 式中，Ar代表6-至14元芳香环基，该环基可具有至少一个取代基；R1、R2、R3、R4、R5、R6、R7和R8彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6烷基或C1-6烷氧基；X代表氧原子或亚甲基；Y代表由式(II)或(III)代表的基团： (其中 Z 代表由式（IV）代表的基团： (其中 R9、R10、R11 和 R12 彼此相同或不同，且各自代表氢原子、卤素原子、羟基、C1-6 烷基或 C1-6 烷氧基））；m 为 0 或 1；n 为 0 或 1。