4,4'-(ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(6,7-dihydroxy-2H-chromen-2-one) | 1447735-15-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4,4'-(ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(6,7-dihydroxy-2H-chromen-2-one)
• 英文别名: 4-[[N-[2-[N-[(6,7-dihydroxy-2-oxochromen-4-yl)methyl]anilino]ethyl]anilino]methyl]-6,7-dihydroxychromen-2-one
• CAS: 1447735-15-0
• 化学式: C₃₄H₂₈N₂O₈
• 分子量: 592.605
• InChiKey: OHIBJXMMVPUNJK-UHFFFAOYSA-N

物化性质

• 沸点：
  912.5±65.0 °C(predicted)
• 密度：
  1.473±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-氯甲基-6,7-二羟基-2-苯并吡酮 、 1,4-二叠氮双环[2.2.2]辛烷 在 三乙胺 作用下， 以 丙酮 为溶剂， 反应 28.0h， 以77%的产率得到4,4'-(ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(6,7-dihydroxy-2H-chromen-2-one)
  参考文献：
  名称：

  Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

  摘要：

  A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.

  DOI：

  10.3109/14756366.2012.692086

文献信息

• Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines
  作者：Bahar Bilgin Sokmen、Gulsah Aydin、Arzu Gumus、Seref Karadeniz、Halil Ibrahim Ugras、Refiye Yanardag、Umit Cakır

  DOI：10.3109/14756366.2012.692086

  日期：2013.8.1

  A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1,1-diphenyl-2-picrylhydrazil (DPPH.) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase activites.