N-(3,5-dichloro-2-morpholinophenyl)picolinamide | 1575753-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-dichloro-2-morpholinophenyl)picolinamide
• 英文别名: N-(3,5-dichloro-2-morpholin-4-ylphenyl)pyridine-2-carboxamide
• CAS: 1575753-87-5
• 化学式: C₁₆H₁₅Cl₂N₃O₂
• 分子量: 352.22
• InChiKey: BJWTYBBGOIKNOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5-二氯苯胺 在 碘苯二乙酸 、 copper(II) acetate monohydrate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 magnesium chloride 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 N-(3,5-dichloro-2-morpholinophenyl)picolinamide
  参考文献：
  名称：

  Copper-Catalyzed Carboxamide-Directed Ortho Amination of Anilines with Alkylamines at Room Temperature

  摘要：

  In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.

  DOI：

  10.1021/ol500464x

文献信息

• Preparation, Characterization, and Reactivity of Aliphatic Amino Iodane(III) Reagents
  作者：Yue Zhang、Jing Lu、Tianlei Lan、Shaoling Cheng、Wei Liu、Chao Chen

  DOI：10.1002/ejoc.202001373

  日期：2021.1.22

  The preparation and X‐ray structural characterization of aliphatic amino iodane (III) reagents has been realized. These new reagents could be used for the Cu‐catalyzed directed electrophilic amination of aryl amines.

  脂肪族氨基碘（III）试剂的制备和X射线结构表征已实现。这些新试剂可用于铜催化的芳基胺的定向亲电子胺化反应。
• Copper-Catalyzed Carboxamide-Directed <i>Ortho</i> Amination of Anilines with Alkylamines at Room Temperature
  作者：Qiong Li、Shu-Yu Zhang、Gang He、Zhaoyan Ai、William A. Nack、Gong Chen

  DOI：10.1021/ol500464x

  日期：2014.3.21

  In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.