2-(3-(trifluoromethyl)phenyl)benzo[b]thiophene | 1276033-51-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-(trifluoromethyl)phenyl)benzo[b]thiophene
• 英文别名: 2-(3-(trifluoromethyl)phenyl)benzothiophene；2-(3-trifluoromethylphenyl)benzothiophene；2-[3-(Trifluoromethyl)phenyl]benzo[b]thiophene；2-[3-(trifluoromethyl)phenyl]-1-benzothiophene
• CAS: 1276033-51-2
• 化学式: C₁₅H₉F₃S
• 分子量: 278.298
• InChiKey: CHKXFIAAFVOWCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基茴香硫醚 在 fluoroboric acid 、 溶剂红 43 、 sodium nitrite 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 14.67h， 生成 2-(3-(trifluoromethyl)phenyl)benzo[b]thiophene
  参考文献：
  名称：

  Visible Light Photocatalytic Synthesis of Benzothiophenes

  摘要：

  The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.

  DOI：

  10.1021/ol302517n

文献信息

• Base-Mediated Intermolecular sp² C−H Bond Arylation via Benzyne Intermediates
  作者：Thanh Truong、Olafs Daugulis

  DOI：10.1021/ja200184b

  日期：2011.3.30

  A transition-metal-free method for arylation of heterocycle and arene carbon-hydrogen bonds by aryl chlorides and fluorides has been developed. The reactions proceed via aryne intermediates and are highly regioselective with respect to the C-H bond coupling component.

  开发了一种无过渡金属的方法，用于通过芳基氯化物和氟化物对杂环和芳烃碳氢键进行芳基化。反应通过芳炔中间体进行，并且对于 CH 键偶联组分具有高度区域选择性。
• Rh(III)-Catalyzed Decarboxylative <i>ortho</i>-Heteroarylation of Aromatic Carboxylic Acids by Using the Carboxylic Acid as a Traceless Directing Group
  作者：Xurong Qin、Denan Sun、Qiulin You、Yangyang Cheng、Jingbo Lan、Jingsong You

  DOI：10.1021/acs.orglett.5b00532

  日期：2015.4.3

  ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh(III)-catalyzed two-fold C–H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.

  芳香族羧酸与各种杂芳烃的高选择性脱羧邻杂芳基化反应是通过Rh（III）催化的2倍C–H活化而开发的，这显示了芳香族羧酸和杂芳烃的广泛底物范围。使用天然存在的羧酸作为导向基团避免了麻烦的用于安装和除去外部导向基团的额外步骤。
• CuI/TMEDA-Catalyzed Annulation of 2-Bromo Alkynylbenzenes with Na₂S: Synthesis of Benzo[<i>b</i>]thiophenes
  作者：Lei-Lei Sun、Chen-Liang Deng、Ri-Yuan Tang、Xing-Guo Zhang

  DOI：10.1021/jo201081v

  日期：2011.9.16

  A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted benzo[b]thiophenes were readily prepared in moderate to good yields by the reaction of 2-bromo alkynylbenzenes and Na2S center dot 9H(2)O.
• Visible Light Photocatalytic Synthesis of Benzothiophenes
  作者：Durga Prasad Hari、Thea Hering、Burkhard König

  DOI：10.1021/ol302517n

  日期：2012.10.19

  The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.