3,5-di-t-butyl-4-hydroxydiphenyl ether | 6839-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-di-t-butyl-4-hydroxydiphenyl ether
• 英文别名: 4-Phenoxy-2,6-di-tert-butylphenol；2,6-Di-tert-butyl-4-phenoxyphenol；2,6-ditert-butyl-4-phenoxyphenol
• CAS: 6839-19-6
• 化学式: C₂₀H₂₆O₂
• 分子量: 298.425
• InChiKey: PAYAXQUETLOOMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,5-di-t-butyl-4-hydroxydiphenyl ether 、 异丙胺 、 环氧氯丙烷 生成 1-(2,6-Di-tert-butyl-4-phenoxy-phenoxy)-3-isopropylamino-propan-2-ol
  参考文献：
  名称：

  Linked aryl aryloxypropanolamines as a new class of lipid catabolic agents

  摘要：

  The synthesis of a series of stilbene, biaryl, tolane, diaryl ether, sulfide, sulfoxide, and sulfone oxypropanolamines as potential antiobesity agents is described. These compounds were evaluated in a mouse lipid catabolism screen, and the more active members of the series, 4, 57, and 58, were further investigated in rats and dogs. 1-(2,6-Ditert-butyl-4-trans-styrylphenoxy)-3-isopropylamino-2-propanol (4) possessed considerable lipid catabolic activity in mice and caused a significant reduction in the body weight of rats after 5 weeks and of dogs after 6 weeks. Only hematological irregularities in a chronic toxicity study precluded further development of this compound as an alternative antiobesity treatment.

  DOI：

  10.1021/jm00200a008
• 作为产物：
  描述：

  2,6-di-t-butyl-4-bromo-4-(1-hydroxypropyl)cyclohexa-2,5-dienone 在 硫酸 、 sodium methylate 、 苯酚 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 反应 0.58h， 生成 3,5-di-t-butyl-4-hydroxydiphenyl ether
  参考文献：
  名称：

  通过4-苯氧基-4-（1-烷氧基）环己-2,5-二烯酮作为可能的中间体，从环己-2,5-二烯酮形成二苯醚

  摘要：

  环己-2,5-二烯酮（3）和（14）与苯酚的酸催化反应得到二苯醚。喹诺醚被认为是这些反应的中间体，通过失去作为驱动力的醛的4-（1-烷氧基）侧链，使环己-2,5-二烯酮环芳构化。

  DOI：

  10.1039/p19810000303

文献信息

• POLYMERIZABLE COMPOSITION, THERMOPLASTIC RESIN COMPOSITION, CROSSLINKED RESIN, AND CROSSLINKED RESIN COMPOSITE MATERIALS
  申请人：ZEON CORPORATION

  公开号：EP1589054A1

  公开（公告）日：2005-10-26

  A polymerizable composition which comprises (i) a cycloolefin monomer, (ii) a metathesis polymerization catalyst, (iii) a chain transfer agent, (iv) a radical crosslinking agent, and (v) a compound (α) selected from the group consisting of compounds having alkoxyphenol structures wherein each aromatic ring has one or more substituents, compounds having aryloxyphenol structures, and compounds having catechol structures wherein each aromatic ring has two or more substituents; a thermoplastic resin composition which comprises (1) a cycloolefin thermoplastic resin, (2) a radical crosslinking agent, and (3) a compound (α) ; a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials produced by laminating a substrate with the thermoplastic resin composition and crosslinking the thermoplastic resin composition. The invention provides a polymerizable composition useful as raw material in the production of a thermoplastic resin composition excellent in storage stability and fluidity in heat lamination; a thermoplastic resin composition and a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials exhibiting excellent interlayer adhesion.

  一种可聚合组合物，它包括(i)环烯烃单体，(ii)偏聚催化剂，(iii)链转移剂，(iv)自由基交联剂，和(v)选自以下组别的化合物(α)：具有烷氧基苯酚结构的化合物，其中每个芳香环有一个或多个取代基；具有芳氧基苯酚结构的化合物；以及具有邻苯二酚结构的化合物，其中每个芳香环有两个或多个取代基；一种热塑性树脂组合物，它包括：(1) 环烯烃热塑性树脂；(2) 自由基交联剂；(3) 化合物 (α)；其生产工艺；通过交联该热塑性树脂组合物而获得的交联树脂；以及通过将基材与该热塑性树脂组合物层压并交联该热塑性树脂组合物而生产的交联树脂复合材料。本发明提供了一种可聚合组合物，可作为生产热塑性树脂组合物的原料，该组合物具有优异的储存稳定性和热层压流动性；一种热塑性树脂组合物及其生产工艺；一种通过交联该热塑性树脂组合物而获得的交联树脂；以及具有优异层间粘合性的交联树脂复合材料。
• KARHU M., J. CHEM. SOC. PERKIN TRANS., 1981, PART 1, NO 1, 303-306
  作者：KARHU M.

  DOI：——

  日期：——
• Polymerizable Composition, Thermoplastic Resin Composition, Crosslinked Resin, And Crosslinked Resin Composite Materials
  申请人：Sugawara Tomoo

  公开号：US20080125531A1

  公开（公告）日：2008-05-29

  A polymerizable composition which comprises (i) a cycloolefin monomer, (ii) a metathesis polymerization catalyst, (iii) a chain transfer agent, (iv) a radical crosslinking agent, and (v) a compound (α) selected from the group consisting of compounds having alkoxyphenol structures wherein each aromatic ring has one or more substituents, compounds having aryloxyphenol structures, and compounds having catechol structures wherein each aromatic ring has two or more substituents; a thermoplastic resin composition which comprises (1) a cycloolefin thermoplastic resin, (2) a radical crosslinking agent, and (3) a compound (α); a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials produced by laminating a substrate with the thermoplastic resin composition and crosslinking the thermoplastic resin composition. The invention provides a polymerizable composition useful as raw material in the production of a thermoplastic resin composition excellent in storage stability and fluidity in heat lamination; a thermoplastic resin composition and a process for the production thereof; a crosslinked resin obtained by crosslinking the thermoplastic resin composition; and crosslinked resin composite materials exhibiting excellent interlayer adhesion.
• US4895907A
  申请人：——

  公开号：US4895907A

  公开（公告）日：1990-01-23
• Linked aryl aryloxypropanolamines as a new class of lipid catabolic agents
  作者：Michael T. Cox、Stuart E. Jaggers、Geraint Jones

  DOI：10.1021/jm00200a008

  日期：1978.2

  The synthesis of a series of stilbene, biaryl, tolane, diaryl ether, sulfide, sulfoxide, and sulfone oxypropanolamines as potential antiobesity agents is described. These compounds were evaluated in a mouse lipid catabolism screen, and the more active members of the series, 4, 57, and 58, were further investigated in rats and dogs. 1-(2,6-Ditert-butyl-4-trans-styrylphenoxy)-3-isopropylamino-2-propanol (4) possessed considerable lipid catabolic activity in mice and caused a significant reduction in the body weight of rats after 5 weeks and of dogs after 6 weeks. Only hematological irregularities in a chronic toxicity study precluded further development of this compound as an alternative antiobesity treatment.