C-p-methoxystyryl-N-methyl nitrone | 106485-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: C-p-methoxystyryl-N-methyl nitrone
• 英文别名: (E)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-imine oxide
• CAS: 106485-09-0；132739-68-5
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: RBLFINIJXCLQCD-GMHKHPCXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C-p-methoxystyryl-N-methyl nitrone 生成 (Z)-N-((E)-3-(4-methoxyphenyl)allylidene)methanamine oxide
  参考文献：
  名称：

  METELITSA, A. V.;KNYAZHANSKIJ, M. I.;VOLBUSHKO, N. V.;NEDZVETSKIJ, V. S.;+, XIMIYA GETEROTSIKL. SOED.,(1990) N0, S. 1373-1378

  摘要：

  DOI：
• 作为产物：
  描述：

  C-(4-methoxyphenyl)-N-methyl nitrone 在 硫酸 作用下， 反应 240.25h， 生成 C-p-methoxystyryl-N-methyl nitrone
  参考文献：
  名称：

  Ring-opening of isoxazolidine system: Homologation of 3-aryl into 3-styryl nitrones via intermediate 5-hydroxy-isoxazolidines.

  摘要：

  High yield conversion of 3-aryl-5-ethoxy-isoxazolidines into 3-styryl nitrones has been achieved by 1,5 h refluxing in aq. H2SO4 or catalytic p-toluensulfonic acid/ethanol media. The rearrangement pathway is interpretable on the basis of the ring-opening process of intermediate 5-hydroxy-isoxazolidines. Formation of a masked 5-OH function has been also developed by basic or acid treatment of 5-acetoxy-isoxazolidines.

  DOI：

  10.1016/s0040-4020(01)88315-0

文献信息

• METELITSA, A. V.;KNYAZHANSKIJ, M. I.;VOLBUSHKO, N. V.;NEDZVETSKIJ, V. S.;+, XIMIYA GETEROTSIKL. SOED.,(1990) N0, S. 1373-1378
  作者：METELITSA, A. V.、KNYAZHANSKIJ, M. I.、VOLBUSHKO, N. V.、NEDZVETSKIJ, V. S.、+

  DOI：——

  日期：——
• UNTERHALT B.; ELJABOUR S., ARCH. PHARM., 1986, 319, N 12, 1146-1150
  作者：UNTERHALT B.、 ELJABOUR S.

  DOI：——

  日期：——
• Ring-opening of isoxazolidine system: Homologation of 3-aryl into 3-styryl nitrones via intermediate 5-hydroxy-isoxazolidines.
  作者：Ugo Chiacchio、Angelo Liguori、Giovanni Romeo、Giovanni Sindona、Nicola Uccella

  DOI：10.1016/s0040-4020(01)88315-0

  日期：1992.1

  High yield conversion of 3-aryl-5-ethoxy-isoxazolidines into 3-styryl nitrones has been achieved by 1,5 h refluxing in aq. H2SO4 or catalytic p-toluensulfonic acid/ethanol media. The rearrangement pathway is interpretable on the basis of the ring-opening process of intermediate 5-hydroxy-isoxazolidines. Formation of a masked 5-OH function has been also developed by basic or acid treatment of 5-acetoxy-isoxazolidines.