(2,2,5-trimethyl-[1,3]-dioxan-5-yl)carbamic acid benzyl ester | 1026527-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,2,5-trimethyl-[1,3]-dioxan-5-yl)carbamic acid benzyl ester
• 英文别名: benzyl(2,2,5-trimethyl-1,3-dioxan-5-yl)carbamate；(2,2,5-Trimethyl-[1,3]dioxan-5-yl)-carbamic acid benzyl ester；benzyl N-(2,2,5-trimethyl-1,3-dioxan-5-yl)carbamate
• CAS: 1026527-88-7
• 化学式: C₁₅H₂₁NO₄
• 分子量: 279.336
• InChiKey: HZSQHWBLIXFTDN-UHFFFAOYSA-N

物化性质

• 沸点：
  400.4±45.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2,2,5-trimethyl-[1,3]-dioxan-5-yl)carbamic acid benzyl ester 在 palladium 10% on activated carbon 、 甲酸铵 作用下， 以 甲醇 为溶剂， 以83%的产率得到2,2,5-trimethyl-[1,3]-dioxan-5-yl amine
  参考文献：
  名称：

  [EN] PHOTOINITATORS
  [FR] PHOTOINITATEURS

  摘要：

  提供了一种包含藿香酮光引发剂基团的光引发剂。

  公开号：

  WO2018095495A1
• 作为产物：
  描述：

  氯甲酸苄酯 、 2,2-二甲氧基丙烷 、 2-氨基-2-甲基-1,3-丙二醇 在 4-甲基苯磺酸吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以38%的产率得到(2,2,5-trimethyl-[1,3]-dioxan-5-yl)carbamic acid benzyl ester
  参考文献：
  名称：

  [EN] PHOTOINITATORS
  [FR] PHOTOINITATEURS

  摘要：

  提供了一种包含藿香酮光引发剂基团的光引发剂。

  公开号：

  WO2018095495A1

文献信息

• ABSORBABLE BRANCHED POLYESTERS AND POLYURETHANES
  申请人：Bezwada Biomedical, LLC

  公开号：US20140142199A1

  公开（公告）日：2014-05-22

  The present invention relates to the discovery of a new class of hydrolysable isocyanates, hydrolysable branched polyols and branched absorbable polyesters and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, stents, highly porous foam, reticulated foam, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers can have a controlled hydrolytic degradation profile.

  本发明涉及一种新型可水解异氰酸酯、可水解支链多元醇及其制备的支链可吸收聚酯和聚氨酯的发现。由此得到的可吸收聚合物可用于药物输送、支架、高孔隙率泡沫、网状泡沫、组织工程、组织粘合剂、防止粘连、骨蜡制剂、医疗设备涂层、表面改性剂以及其他可植入医疗设备。此外，这些可吸收聚合物可以具有受控的水解降解特性。
• [EN] PHOTOINITATORS<br/>[FR] PHOTOINITATEURS
  申请人：COLOPLAST AS

  公开号：WO2018095495A1

  公开（公告）日：2018-05-31

  A photoinitiator is provided which incorporates a camphorquinone photoinitiator moiety.

  提供了一种包含藿香酮光引发剂基团的光引发剂。
• Photoinitators
  申请人：Coloplast A/S

  公开号：US10696626B2

  公开（公告）日：2020-06-30

  A photoinitiator is provided which incorporates a camphorquinone photoinitiator moiety.

  提供了一种包含樟脑醌光引发剂分子的光引发剂。
• PHOTOINITATORS
  申请人：Coloplast A/S

  公开号：EP3545009B1

  公开（公告）日：2021-07-21
• Synthesis of Furanonaphthoquinones with Hydroxyamino Side Chains
  作者：Chongming Wu、Randall K. Johnson、Michael R. Mattern、Jackson C. Wong、David G. I. Kingston

  DOI：10.1021/np9900019

  日期：1999.7.1

  Several furanonaphthoquinones have shown useful activity in a yeast assay for DNA-damaging agents and cytotoxicity in mammalian cell culture assays. These results, together with the planar aromatic character of the furanonaphthoquinones, suggested that they might be acting as DNA intercalators. In an attempt to improve this activity, various analogues containing a hydroxyamino side chain have been synthesized. The analogues were prepared by standard methods, but some unexpected reactions were observed nonetheless. Thus, 8-formyl-5-methoxy-4,9-dihydronaphtho[2,3-b]furan-4,9-dione (24) showed an unusual reactivity toward reductive amination, with the reaction proceeding further to give one of two different cyclized products, depending on the amination reagent used. Bioassay results indicated that only simple furanonaphthoquines showed activity in a yeast assay for DNA-damaging agents; compounds with a substituted hydroxyamino side chain were uniformly inactive in this assay. Most of the compounds with a substituted hydroxyamino side chain on the furan ring did, however, show cytotoxicity, although none of them was any more active than the simple aldehyde 2-formyl-4,9-dihydronaphtho[2,3-b]furan-4,9-dione (14). This evidence tends to suggest that the furanonaphthoquinones do not serve primarily as DNA intercalators, because if this were the case, they would have been expected to show an increased activity on conversion to their hydroxyamino side chain derivatives.