5-(4-chlorophenyl)-7-(pyridin-2-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dithione | 906652-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(4-chlorophenyl)-7-(pyridin-2-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dithione
• 英文别名: 5-(4-chlorophenyl)-7-pyridin-2-yl-1H-pyrido[2,3-d]pyrimidine-2,4-dithione
• CAS: 906652-85-5
• 化学式: C₁₈H₁₁ClN₄S₂
• 分子量: 382.897
• InChiKey: QBXAJYURBGLSGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(4-chlorophenyl)-7-(pyridin-2-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dithione 在 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 反应 3.0h， 生成 7-(4-chlorobenzylidene)-4-(4-chlorophenyl)-2-(pyridin-2-yl)-5-thioxo-pyrido[2',3':4,5]pyrimido[2,1-b][1,3]thiazol-8-one
  参考文献：
  名称：

  Preparation of Some Fused Pyridopyrimidine and Pyridothienotriazine Derivatives for Biological Evaluation

  摘要：

  Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone (1) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative 2 was in turn used as a precursor for the preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used for the preparation of thienopyridine derivatives 11 and 12. Nitrozation of compound 12 afforded pyridothienotriazine derivative 13. Some of the prepared products showed potent antimicrobial activity.

  DOI：

  10.1080/104265090968118
• 作为产物：
  描述：

  3-(4-氯苯基)-1-(吡啶-2-基)丙-2-烯-1-酮 在 乙酸铵 、 氢氧化钾 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 5-(4-chlorophenyl)-7-(pyridin-2-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dithione
  参考文献：
  名称：

  Preparation of Some Fused Pyridopyrimidine and Pyridothienotriazine Derivatives for Biological Evaluation

  摘要：

  Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone (1) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative 2 was in turn used as a precursor for the preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used for the preparation of thienopyridine derivatives 11 and 12. Nitrozation of compound 12 afforded pyridothienotriazine derivative 13. Some of the prepared products showed potent antimicrobial activity.

  DOI：

  10.1080/104265090968118

文献信息

• Preparation of Some Fused Pyridopyrimidine and Pyridothienotriazine Derivatives for Biological Evaluation
  作者：A. E. Rashad、H. H. Sayed、A. H. Shamroukh、H. M. Awad

  DOI：10.1080/104265090968118

  日期：2005.12

  Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone (1) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative 2 was in turn used as a precursor for the preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used for the preparation of thienopyridine derivatives 11 and 12. Nitrozation of compound 12 afforded pyridothienotriazine derivative 13. Some of the prepared products showed potent antimicrobial activity.