2,2-dimethyl-pent-4-enoic acid amide | 97228-73-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-dimethyl-pent-4-enoic acid amide
• 英文别名: 2,2-dimethyl-4-pentenamide；2,2-dimethylpent-4-enamide；2,2-Dimethyl-pent-4-ensaeure-amid
• CAS: 97228-73-4
• 化学式: C₇H₁₃NO
• mdl: MFCD19204542
• 分子量: 127.186
• InChiKey: RXUSSMGQGUFCNU-UHFFFAOYSA-N

物化性质

• 熔点：
  80-81 °C
• 沸点：
  234.0±19.0 °C(Predicted)
• 密度：
  0.908±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-pent-4-enoic acid amide 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 (4S)-N-(2,2-dimethylpent-4-enoyl)-2,2-dimethyl-4-propan-2-yl-1,3-oxazolidine-3-carboxamide
  参考文献：
  名称：

  Asymmetric Iodolactamization Induced by Chiral Oxazolidine Auxiliary

  摘要：

  Asymmetric iodolactamization reactions of unsaturated amides with oxazolidines as the chiral auxiliaries were investigated. With (4S)-4-((2R)-2-butyl)-2,2-dimethyloxazolidine as the auxiliary and LiH as the base, a number of unsaturated amides underwent iodolactamization smoothly to afford the corresponding gamma- and delta-lactams in 30-98% yield with de values up to 97%.

  DOI：

  10.1021/jo0488006
• 作为产物：
  描述：

  2,2-二甲基-4-戊烯酸 生成 2,2-dimethyl-pent-4-enoic acid amide
  参考文献：
  名称：

  The Formation of 3,3,5-Trimethyl-2-pyrrolidone by the Cleavage of 5-Ethoxy-2,2-dimethylvalerophenone with Sodamide¹

  摘要：

  DOI：

  10.1021/ja01610a004

文献信息

• Sulphonamido-substituted bridged bicycloalkyl derivatives
  申请人：——

  公开号：US20040029862A1

  公开（公告）日：2004-02-12

  A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

  揭示了一类化合物，包括磺胺基取代的桥联双环烷基结构。这些化合物是γ-分泌酶的抑制剂，因此在治疗和/或预防阿尔茨海默病方面是有用的。
• Copper(II) Carboxylate-Promoted Intramolecular Carboamination of Alkenes for the Synthesis of Polycyclic Lactams
  作者：Peter H. Fuller、Sherry R. Chemler

  DOI：10.1021/ol702401w

  日期：2007.12.1

  intramolecular carboamination reactions of variously substituted gamma-alkenyl amides have been investigated. These oxidative cyclization reactions efficiently provide polycyclic lactams, useful intermediates in nitrogen heterocycle synthesis, in good to excellent yields. The efficiency of the carboamination process is dependent upon the structure of the amide backbone as well as the nitrogen substituent.

  已经研究了羧酸铜 (II) 促进的各种取代 γ-烯基酰胺的分子内碳胺化反应。这些氧化环化反应有效地提供了多环内酰胺，它是氮杂环合成中有用的中间体，产率很高。碳胺化过程的效率取决于酰胺主链的结构以及氮取代基。
• Sulfamides as gamma-secretase inhibitors
  申请人：——

  公开号：US20040049038A1

  公开（公告）日：2004-03-11

  Novel sulfamides of formula (1) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.

  本发明揭示了式（1）的新型磺胺类化合物。这些化合物对γ-分泌酶加工APP具有抑制作用，因此可用于治疗或预防阿尔茨海默病。
• The Formation of 3,3,5-Trimethyl-2-pyrrolidone by the Cleavage of 5-Ethoxy-2,2-dimethylvalerophenone with Sodamide¹
  作者：Ronald F. Brown、Norman M. van Gulick

  DOI：10.1021/ja01610a004

  日期：1955.3
• SULPHONAMIDO-SUBSTITUTED BRIDGED BICYCLOALKYL DERIVATIVES
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1268412A1

  公开（公告）日：2003-01-02