1,1'-Bis-(2-chloro-ethyl)-2,2'-diphenyl-[3,3']biindolizinyl | 189816-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,1'-Bis-(2-chloro-ethyl)-2,2'-diphenyl-[3,3']biindolizinyl
• 英文别名: 1,1'-Bis(2-chloroethyl)-2,2'-diphenyl-3,3'-biindolizine；1-(2-chloroethyl)-3-[1-(2-chloroethyl)-2-phenylindolizin-3-yl]-2-phenylindolizine
• CAS: 189816-30-6
• 化学式: C₃₂H₂₆Cl₂N₂
• 分子量: 509.478
• InChiKey: CFMGVOPTHASIJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  8.8
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  lithium di-(o-tolyl)-phosphide 、 1,1'-Bis-(2-chloro-ethyl)-2,2'-diphenyl-[3,3']biindolizinyl 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 3,3'-bis<1-(3-di-o-tolyl-phosphinoethyl)-2-phenylindolizine>
  参考文献：
  名称：

  PHOSPHINE- AND PHOSPHITE-SUBSTITUTED 3,3′-BI-INDOLIZINES- NEW ATROPISOMERIC LIGANDS

  摘要：

  For the first time enantiomerically pure phosphine- or phosphite-substituted 1,1'-alkyl-3,3'-bi-indolizines were obtained. In situ prepared rhodium complexes of these compounds were tested in hydroformylation of styrene and methylstyrene.

  DOI：

  10.1080/10426509808036970
• 作为产物：
  描述：

  2-[1'-(2-Hydroxy-ethyl)-2,2'-diphenyl-[3,3']biindolizinyl-1-yl]-ethanol 在 四氯化碳 、 三苯基膦 作用下， 以 乙腈 为溶剂， 生成 1,1'-Bis-(2-chloro-ethyl)-2,2'-diphenyl-[3,3']biindolizinyl
  参考文献：
  名称：

  Chlorination of enantiomerically pure 1,1′-bis(hydroxyalkyl)-3,3′-biindolizines: conservation of chirality by thermal treatment

  摘要：

  Enantiomerically pure 1,1′-bis(hydroxyalkyl)-3,3′-biindolizines 1 racemize unexpectedly by reaction with tetra-chloromethane–triphenylphosphine at room temperature affording the corresponding dichloro compounds 2, whereas the chirality is preserved at higher reaction temperatures.

  DOI：

  10.1039/a607703j

文献信息

• PHOSPHINE- AND PHOSPHITE-SUBSTITUTED 3,3′-BI-INDOLIZINES- NEW ATROPISOMERIC LIGANDS
  作者：Angela Köckritz、Helmut Sonnenschein、Stefan Bischoff、Fritz Theil、Jörg Gloede

  DOI：10.1080/10426509808036970

  日期：1998.1.1

  For the first time enantiomerically pure phosphine- or phosphite-substituted 1,1'-alkyl-3,3'-bi-indolizines were obtained. In situ prepared rhodium complexes of these compounds were tested in hydroformylation of styrene and methylstyrene.
• Chlorination of enantiomerically pure 1,1′-bis(hydroxyalkyl)-3,3′-biindolizines: conservation of chirality by thermal treatment
  作者：Helmut Sonnenschein、Fritz Theil、Thomas Kreher、Angela Köckritz

  DOI：10.1039/a607703j

  日期：——

  Enantiomerically pure 1,1′-bis(hydroxyalkyl)-3,3′-biindolizines 1 racemize unexpectedly by reaction with tetra-chloromethane–triphenylphosphine at room temperature affording the corresponding dichloro compounds 2, whereas the chirality is preserved at higher reaction temperatures.