1-O-benzoyl-2,3,4-tri-O-benzyl-D-galactitol | 212691-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-O-benzoyl-2,3,4-tri-O-benzyl-D-galactitol
• 英文别名: [(2S,3R,4S,5R)-5,6-dihydroxy-2,3,4-tris(phenylmethoxy)hexyl] benzoate
• CAS: 212691-22-0
• 化学式: C₃₄H₃₆O₇
• 分子量: 556.656
• InChiKey: KKNONLZNQKFPPV-JDIHBLRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  41
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  94.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-O-benzoyl-2,3,4-tri-O-benzyl-D-galactitol 在 sodium periodate 作用下， 以 水 、 丙酮 为溶剂， 以88%的产率得到1-O-benzoyl-2,3,4-tri-O-benzyl-L-lyxose
  参考文献：
  名称：

  Synthesis of an imidazolo-L-lyxo-piperidinose derivative

  摘要：

  Imidazolo-L-lyxo-piperidinose 4 was synthesised from the D-galactose derivative 8 by two reaction sequences via removal of a terminal carbon atom stepwise incorporation of an imidazole moiety, and eventually intramolecular S(N)2 reaction to the corresponding piperidine ring. Piperidinose 4 proved to be a poor glycosidase inhibitor. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00561-4
• 作为产物：
  描述：

  2,3,4-tri-O-benzyl-5,6-O-isopropylidene-D-galactose 在 sodium tetrahydroborate 、 水 作用下， 以 吡啶 、 甲醇 、 溶剂黄146 为溶剂， 反应 8.0h， 生成 1-O-benzoyl-2,3,4-tri-O-benzyl-D-galactitol
  参考文献：
  名称：

  Synthesis of an imidazolo-L-lyxo-piperidinose derivative

  摘要：

  Imidazolo-L-lyxo-piperidinose 4 was synthesised from the D-galactose derivative 8 by two reaction sequences via removal of a terminal carbon atom stepwise incorporation of an imidazole moiety, and eventually intramolecular S(N)2 reaction to the corresponding piperidine ring. Piperidinose 4 proved to be a poor glycosidase inhibitor. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00561-4

文献信息

• Synthesis of an imidazolo-L-lyxo-piperidinose derivative
  作者：Andrzej Frankowski、Dariusz Deredas、Jacques Streith、Théophile Tschamber

  DOI：10.1016/s0040-4020(98)00561-4

  日期：1998.7

  Imidazolo-L-lyxo-piperidinose 4 was synthesised from the D-galactose derivative 8 by two reaction sequences via removal of a terminal carbon atom stepwise incorporation of an imidazole moiety, and eventually intramolecular S(N)2 reaction to the corresponding piperidine ring. Piperidinose 4 proved to be a poor glycosidase inhibitor. (C) 1998 Elsevier Science Ltd. All rights reserved.