2-(2-naphtho-[2.1-b]-furanyl)-benzoxazole | 31773-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 2-(2-naphtho-[2.1-b]-furanyl)-benzoxazole
• 英文别名: 2-Benzo[e][1]benzofuran-2-yl-1,3-benzoxazole
• CAS: 31773-12-3
• 化学式: C₁₉H₁₁NO₂
• 分子量: 285.302
• InChiKey: UQOCGIVWZSIQOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-萘氧乙酸 在 sodium hydroxide 、 磷酸 、 硼酸 、 phosphorus pentoxide 、 三氯氧磷 作用下， 以 乙二醇 为溶剂， 反应 8.0h， 生成 2-(2-naphtho-[2.1-b]-furanyl)-benzoxazole
  参考文献：
  名称：

  Shekar, P. C.; Seshadri, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 477 - 480

  摘要：

  DOI：

文献信息

• Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them
  申请人：3V SIGMA S.p.A

  公开号：EP0722714A2

  公开（公告）日：1996-07-24

  Benzoxazole derivatives having the following formula (I): wherein the groups are hereinafter defined are disclosed together with the use thereof as sunscreen agents and cosmetic compositions containing them.

  具有下式 (I) 的苯并恶唑衍生物： 的苯并恶唑衍生物，以及它们作为防晒剂和含有它们的化妆品组合物的用途。
• Highly efficient copper/palladium-catalyzed tandem Ullman reaction/arylation of azoles via C–H activation: synthesis of benzofuranyl and indolyl azoles from 2-(gem-dibromovinyl)phenols(anilines) with azoles
  作者：Wei Chen、Min Wang、Pinhua Li、Lei Wang

  DOI：10.1016/j.tet.2011.06.044

  日期：2011.8

  In this paper, a novel and highly efficient copper/palladium-catalyzed tandem intramolecular Ullman-type C-O(N) coupling reaction of 2-(gem-dibromovinyl)phenols(anilines) followed by an intermolecular arylation of azoles through C-H activation has been developed. In the presence of CuBr with Pd(PPh3)(2)Cl-2 used as co-catalyst, and (LiOBu)-Bu-t as a base, the one-pot reactions of 2-(gem-dibromovinyl)phenols and 2-(gem-dibromovinyl)anilines with a variety of azoles, including oxazoles, imidazoles, thiazoles, and oxadiazoles underwent smoothly in toluene at 100 degrees C to generate the corresponding biheteroaryl products in high yields. A tentative mechanism of copper/palladium-catalyzed tandem reaction was described. (C) 2011 Elsevier Ltd. All rights reserved.
• US5518713A
  申请人：——

  公开号：US5518713A

  公开（公告）日：1996-05-21