1-(2-Chloro-ethoxy)-pyrrolidine-2,5-dione | 213249-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Chloro-ethoxy)-pyrrolidine-2,5-dione
• 英文别名: 1-(2-Chloroethoxy)pyrrolidine-2,5-dione
• CAS: 213249-24-2
• 化学式: C₆H₈ClNO₃
• 分子量: 177.587
• InChiKey: IRRAIKKRJPNPQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 1,2-二氯乙烷 在 三乙胺 作用下， 反应 48.0h， 以71.5%的产率得到1-(2-Chloro-ethoxy)-pyrrolidine-2,5-dione
  参考文献：
  名称：

  Studies on the reactions of HOBt, HOOBt, HOSu with dichloroalkane solvents

  摘要：

  The well known peptide synthesis reagents HOBt, HOOBt and HOSu were found to react with chloroalkane solvents in the presence of triethylamine. Six new compounds were obtained and characterized. (C) 1998 Elsevier Science Ltd. AII rights reserved.

  DOI：

  10.1016/s0040-4039(98)01406-3

文献信息

• Studies on the reactions of HOBt, HOOBt, HOSu with dichloroalkane solvents
  作者：Jian-guo Ji、De-yi Zhang、Yun-hua Ye、Qi-yi Xing

  DOI：10.1016/s0040-4039(98)01406-3

  日期：1998.9

  The well known peptide synthesis reagents HOBt, HOOBt and HOSu were found to react with chloroalkane solvents in the presence of triethylamine. Six new compounds were obtained and characterized. (C) 1998 Elsevier Science Ltd. AII rights reserved.