N,N-dicyclohexylisobutyramide | 117264-61-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-dicyclohexylisobutyramide
• 英文别名: N,N-dicyclohexyl-2-methylpropanamide
• CAS: 117264-61-6
• 化学式: C₁₆H₂₉NO
• mdl: MFCD01353620
• 分子量: 251.412
• InChiKey: BUFHMXOHXTZRDH-UHFFFAOYSA-N

物化性质

• 沸点：
  372.1±9.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.937
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-dicyclohexylisobutyramide 在 deutero lithium aluminiumhydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以399 mg的产率得到N,N-dicyclohexyl-1,1-dideuterio-2-methyl-1-propanamine
  参考文献：
  名称：

  A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones

  摘要：

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.

  DOI：

  10.1021/ol2014895
• 作为产物：
  描述：

  异丁酸酐 、 二环己胺 在 4-二甲氨基吡啶 作用下， 反应 3.0h， 生成 N,N-dicyclohexylisobutyramide
  参考文献：
  名称：

  A Tertiary Amine as A Hydride Donor: Trichlorosilyl Triflate-mediated Conjugate Reduction of Unsaturated Ketones

  摘要：

  Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced alpha,beta-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones In excellent yields. Isotope-labeling studies revealed that an alpha-hydrogen of the amine was transferred to the enones during reduction.

  DOI：

  10.1021/ol2014895

文献信息

• Pd-catalysed β-selective C(sp³)–H arylation of simple amides
  作者：Hong-Yan Hao、Shao-Jie Lou、Shuang Wang、Kun Zhou、Qiu-Zi Wu、Yang-Jie Mao、Zhen-Yuan Xu、Dan-Qian Xu

  DOI：10.1039/d1cc02261j

  日期：——

  An efficient Pd-catalysed β-C(sp3)–H arylation of diverse native amides with aryl iodides was developed. This protocol overcomes the necessity of the Thorpe–Ingold effect and features broad substrate scope and good functional group tolerance. The potential application of this protocol is collectively demonstrated by gram-scale synthesis and the synthesis of several bioactive molecules.

  开发了一种有效的 Pd 催化的 β-C(sp 3 )-H 芳基化多种天然酰胺与芳基碘化物的芳基化反应。该协议克服了索普-英戈尔德效应的必要性，具有广泛的底物范围和良好的官能团耐受性。该协议的潜在应用由克级合成和几种生物活性分子的合成共同证明。
• ARYL TRIAZOLE CAGES
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20210363150A1

  公开（公告）日：2021-11-25

  The present disclosure concerns synthesis, anion binding features, liquid-liquid extraction of salts, and anti-corrosion character of aryl-triazole bicyclic macrocycles of Formula (I) and related compounds: