5-ethylnonan-4-ol | 19780-73-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-ethylnonan-4-ol
• 英文别名: 5-Aethyl-nonan-4-ol；5-Ethyl-4-nonanol
• CAS: 19780-73-5
• 化学式: C₁₁H₂₄O
• 分子量: 172.311
• InChiKey: UWOWBSBTVUWTFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-ethylnonan-4-ol 在 chromium(III) oxide 、 硫酸 作用下， 生成 5-ethyl 4-nonanone
  参考文献：
  名称：

  Powell; Nielsen, Journal of the American Chemical Society, 1948, vol. 70, p. 3629

  摘要：

  DOI：
• 作为产物：
  描述：

  4-庚酮 在 氢氧化钾 、 乙醚 、 碘 、 sodium 作用下， 生成 5-ethylnonan-4-ol
  参考文献：
  名称：

  Powell; Nielsen, Journal of the American Chemical Society, 1948, vol. 70, p. 3629

  摘要：

  DOI：

文献信息

• Highly regioselective reaction of zirconocene-alkene complexes with aldehydes or ketones
  作者：Noriyuki Suzuki、Christophe J. Rousset、Koichiro Aoyagi、Martin Kotora、Tamotsu Takahashi、Maki Hasegawa、Yu Nitto、Masahiko Saburi

  DOI：10.1016/0022-328x(94)80112-6

  日期：1994.6

  Reactions of zirconocene-alkene complexes Cp2Zr(CH2CHR)(PR′3) (R  H, Me, Et, SiR″3 or Ar) with aldehydes or ketones were investigated. Zirconocene-ethylene, -propylene or 1-butene complexes reacted with aldehydes or ketones at terminal carbons of alkenes to give the corresponding alcohols after hydrolysis with a high regioselectivity. A similar type of reaction product was also obtained by a reaction

  的锆-烯烃络合物的Cp反应2的Zr（CH 2 CHR）（PR' 3）（RH，ME等，先生“ 3或Ar）与醛或酮的关系进行了研究。锆茂-乙烯，-丙烯或1-丁烯络合物在烯烃的末端碳上与醛或酮反应，在水解后具有高区域选择性，得到相应的醇。氧化锆环戊烷与醛的反应也获得了相似类型的反应产物。该反应通过锆碳环戊烷的β-β'碳-碳键裂解进行。锆茂-乙烯基硅烷络合物与酮的反应得到具有优异区域选择性的3-三甲基甲硅烷基-1-氧杂-2-氧化锆环戊烷。碳-碳键的形成仅发生在乙烯基硅烷的末端碳上。水解后得到它们相应的γ-甲硅烷基醇。产物表明，乙烯基硅烷与β-碳上的羰基化合物反应生成甲硅烷基。它与乙烯基硅烷的常规反应形成鲜明对比，后者的α-碳通常会侵蚀亲电体。苯乙烯及其衍生物与戊烷-3-酮在锆上的反应产生了两种区域异构体的混合物。在1-氧杂-2-氧化锆环戊烷中，烯烃的取代基倾向于位于Zr的α位。该取向显示了由锆
• Method for Producing Aldehyde and Ketone
  申请人：Yamashita Miyoshi

  公开号：US20110282102A1

  公开（公告）日：2011-11-17

  Provided is a highly efficient method for the production of aldehydes and ketones, which is inexpensive, exhibits high reactivity, and is capable of easy separation of byproduct after the reaction. More particularly, there is provided a method for producing an aldehyde or a ketone, comprising at least an oxidation step of oxidizing a primary alcohol or a secondary alcohol in the presence of a polymeric carbodiimide represented by the following formula (1) and having a weight-average molecular weight of 300 to 5000, and a sulfoxide compound, together with an acid and a base, or together with a salt of the acid and the base.

  提供了一种高效的生产醛和酮的方法，该方法廉价、具有高反应性，并能够在反应后轻松分离副产物。更具体地，提供了一种生产醛或酮的方法，包括至少一个氧化步骤，即在聚合物碳二亚胺（表示为以下式（1）且具有分子量为300至5000的重均分子量）和亚砜化合物的存在下氧化一级醇或二级醇，以及酸和碱，或者酸和碱的盐。
• Zirconium Mediated Regioselective Carbon-Carbon Bond Formation Reactions
  作者：Tamotsu Takahashi、Noriyuki Suzuki、Maki Hasegawa、Yu Nitto、Ko-ichiro Aoyagi、Masahiko Saburi

  DOI：10.1246/cl.1992.331

  日期：1992.2

  Reactions of zirconocene-alkene complexes with aldehydes gave alcohols as coupling products after hydrolysis. The carbon-carbon bond formation proceeded at C1 carbon of alkenes, in sharp contrast to the reactions of alkene-alkene coupling on zirconium. A similar alcohol was also obtained by the reaction of zirconacyclopentane with aldehyde after hydrolysis. Treatment of (C5Me5)2ZrEt2 with styrene gave

  锆茂-烯烃配合物与醛的反应在水解后得到醇作为偶联产物。碳-碳键的形成是在烯烃的 C1 碳上进行的，这与烯烃-烯烃偶联在锆上的反应形成鲜明对比。通过水解后的锆并环戊烷与醛反应也得到类似的醇。(C5Me5)2ZrEt2 用苯乙烯处理水解后得到 2-苯基丁烷，这与 Cp2ZrEt2 得到 1-苯基丁烷的情况相反。
• AZA-BRIDGED-RING COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2119716A1

  公开（公告）日：2009-11-18

  [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like. [MEANS FOR SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

  [问题]本发明提供了一种化合物，该化合物对毒蕈碱 M3 受体具有拮抗作用，可用作慢性阻塞性肺病 （COPD）、哮喘等炎症疾病的预防和/或治疗剂的活性成分。 [解决问题的方法]本发明者对一种对毒蕈碱类 M3 受体的结合具有拮抗作用的化合物进行了研究，他们发现一种杂环桥环化合物或其盐对毒蕈碱类 M3 受体的结合具有拮抗作用，从而完成了本发明。本发明的杂环桥环化合物对毒蕈碱类 M3 受体的结合具有拮抗作用，可用作慢性阻塞性肺病（COPD）、哮喘等炎症疾病的预防和/或治疗剂。
• Method for producing aldehyde and ketone
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2386535A1

  公开（公告）日：2011-11-16

  Provided is a highly efficient method for the production of aldehydes and ketones, which is inexpensive, exhibits high reactivity, and is capable of easy separation of byproduct after the reaction. More particularly, there is provided a method for producing an aldehyde or a ketone, comprising at least an oxidation step of oxidizing a primary alcohol or a secondary alcohol in the presence of a polymeric carbodiimide represented by the following formula (1) and having a weight-average molecular weight of 300 to 5000, and a sulfoxide compound, together with an acid and a base, or together with a salt of the acid and the base.          R1―N=C=N―(R3―N=C=N)―nR2     (1)

  本发明提供了一种生产醛和酮的高效方法，该方法成本低廉，反应活性高，且反应后的副产物易于分离。更具体地说，本发明提供了一种生产醛或酮的方法，该方法至少包括一个氧化步骤，即在由下式（1）表示的、重量平均分子量为 300 至 5000 的聚合物碳二亚胺和亚砜化合物以及酸和碱或酸和碱的盐的存在下，氧化伯醇或仲醇。 R1-N=C=N-(R3-N=C=N)-nR2 (1)