4-cyanophenol-d4 | 1025089-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyanophenol-d4
• 英文别名: 4-Cyanophenol-2,3,5,6-d4；2,3,5,6-tetradeuterio-4-hydroxybenzonitrile
• CAS: 1025089-21-7
• 化学式: C₇H₅NO
• 分子量: 123.091
• InChiKey: CVNOWLNNPYYEOH-RHQRLBAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-cyanophenol-d4 、 (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide 在 sodium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以59.9%的产率得到(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide-d4
  参考文献：
  名称：

  [EN] METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF
  [FR] MÉTABOLITES DE MODULATEURS DE RÉCEPTEUR ANDROGÈNE SÉLECTIFS ET PROCÉDÉS D'UTILISATION DE CEUX-CI

  摘要：

  这项发明提供了SARM化合物的代谢产物，包括葡萄糖醛酸酯化合物等，并利用它们在治疗受试者中的多种疾病或症状，包括但不限于肌肉消耗疾病和/或紊乱、与骨相关的疾病和/或紊乱、代谢综合征、糖尿病及相关疾病等。

  公开号：

  WO2009155481A1

文献信息

• METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF
  申请人：VEVERKA Karen A.

  公开号：US20100004326A1

  公开（公告）日：2010-01-07

  This invention provides metabolites of SARM compounds including inter alia glucuronidated metabolites and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, muscle wasting disease and/or disorder, a bone related disease and/or disorder, metabolic syndrome, diabetes and associated diseases, and others.

  这项发明提供了SARM化合物的代谢产物，包括葡萄糖醛酸化代谢产物等，以及它们在治疗受试者的各种疾病或病况中的用途，包括但不限于肌肉消耗性疾病和/或紊乱，骨相关疾病和/或紊乱，代谢综合症，糖尿病及相关疾病等。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US8003689B2
  申请人：——

  公开号：US8003689B2

  公开（公告）日：2011-08-23