4-chloro-2-methoxy-5-nitrobenzoic acid | 68255-77-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-2-methoxy-5-nitrobenzoic acid
• 英文别名: 2-methoxy-4-chloro-5-nitrobenzoic acid；4-chloro-5-nitro-o-anisic acid；4-Chlor-2-methoxy-5-nitro-benzoesaeure
• CAS: 68255-77-6
• 化学式: C₈H₆ClNO₅
• 分子量: 231.592
• InChiKey: RSBXOVZBSUWTCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  4-chloro-2-methoxy-5-nitrobenzoic acid 以 甲醇 、 氩 为溶剂， 生成 2，4-二甲氧基-5-硝基苯甲酸
  参考文献：
  名称：

  N-(3-pyrrolidinyl) benzamide derivative

  摘要：

  以下一般式（I）代表的N-(3-吡咯基)苯甲酰衍生物具有对多巴胺D.sub.3和/或D.sub.4受体的强效选择性拮抗作用，可用作精神药物、治疗精神分裂症的药物等，或其药学上可接受的盐或药物制剂。

  公开号：

  US05686482A1
• 作为产物：
  描述：

  4-氯-2-硝基苯甲酸 在 氢氧化钾 、 硫酸 、 硝酸 作用下， 生成 4-chloro-2-methoxy-5-nitrobenzoic acid
  参考文献：
  名称：

  Progress and records in the study of endogenetic mineralization during collisional orogenesis

  摘要：

  To develop and perfect the theory of plate tectonics and regional metallogeny, metallogenesis during collisional orogenesis should be thoroughly studied and wilt attract increasing attention of more and more scientists. This paper presents the main aspects of research and discussions on metallogenesis during collisional orogenesis after the development of plate tectonics, and accordingly divides the study history into two stages, i.e. the junior stage during 1971-1990 and the senior stage after 1990. Beginning with the negation of mineralization in the collision regime by Guild (1971), the focus of study was put on whether there occurred any mineralization during collisional orogenesis at the junior stage. At the senior stage, which is initiated by the advance of metallogenic and petrogenic model for collisional orogenesis, scientists begin to pay their attention to the geodynamic mechanism of metallogenesis, spatial and temporal distribution of ore deposits, ore-forming fluidization, relationship between petrogenesis and mineralization in collisional orogenesis, etc, Abundance of typical collisional orogens such as Himalayan, China has best natural conditions to study collisional metallogenesis. Great progress in the study of metallogenesis during collisional orogenesis has been made by Chinese geologists. Therefore, we hope that the Chinese geologists and Chinese governments at various levels to pay more attention to the study of collisional metallogenesis. Some urgent problems are suggested to be solved so as to bring about breakthroughs in the aspects concerned.

  DOI：

  10.1007/bf02884893

文献信息

• Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides
  作者：Shiro Kato、Toshiya Morie、Katsuhiko Hino、Tatsuya Kon、Shunsuke Naruto、Naoyuki Yoshida、Tadahiko Karasawa、Junichi Matsumoto

  DOI：10.1021/jm00167a020

  日期：1990.5

  With the purpose of obtaining more potent and selective gastric prokinetic than metoclopramide (1), a new series of N-[(2-morpholinyl)alkyl]benzamides (17-52) were synthesized and their gastric prokinetic activity was evaluated by determining effects on the gastric emptying of phenol red semisolid meal and of resin pellets solid meal in rats and mice. The morpholinyl moiety was newly designed after

  为了获得比甲氧氯普胺（1）更有效和选择性的胃动力，合成了一系列新的N-[（2-吗啉基）烷基]苯甲酰胺（17-52），并通过测定对胃泌素的作用来评估其胃动力。大鼠和小鼠胃中酚红半固体粉和树脂颗粒固体粉的胃排空。考虑到西沙必利（2）的侧链结构后，新设计了吗啉基部分，并与甲氧氯普胺和西沙必利的4-氨基-5-氯-2-甲氧基苯甲酰基偶联时产生了所需的活性。苯甲酰基的取代基的改性显着影响了活性。特别是，
• [EN] FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PYRAZOLE KINASE FUSIONNEE TRICYCLIQUE ET TETRACYCLIQUE
  申请人：ABBOTT LAB

  公开号：WO2004080973A1

  公开（公告）日：2004-09-23

  Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有化学式(I) (I)的化合物对抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物，以及使用这些化合物进行治疗的方法。
• Benzopiperidine derivatives
  申请人：Eisai Co., Ltd.

  公开号：US06518423B1

  公开（公告）日：2003-02-11

  Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.

  本茨哌啶衍生物，由公式(I)表示，其盐或水合物，其制备方法以及包含其的药物: 其中变量如说明书中所述。这些化合物作为药物有效，用于预防和治疗这些各种炎症性疾病和免疫性疾病，如类风湿性关节炎、特应性皮炎、银屑病、哮喘和伴随器官移植的排斥反应。
• 4-(aroylamino)piperidine-butanimide derivatives
  申请人：Janssen Pharmaceutica

  公开号：US04990521A1

  公开（公告）日：1991-02-05

  A method of treating warm-blooded animals suffering from diarrhea, which method comprises the administration of particular 4-(aroylamino)piperidinebutanamide derivatives and compositions containing the same. Novel 4-(aroylamino)piperidinebutanamide derivatives.

  一种治疗患有腹泻的温血动物的方法，该方法包括给予特定的4-(芳酰氨基)哌啶丁酰胺衍生物和包含相同成分的制剂。新型的4-(芳酰氨基)哌啶丁酰胺衍生物。
• 3-QUINOLINE-2-(1H)-YLIDENEINDOLIN-2-ONE DERIVATIVES
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1396490A1

  公开（公告）日：2004-03-10

  There is provided medicaments, particularly a vascular endothelial growth factor (VEGF) inhibitor which is useful as a therapeutic drug for solid tumors, diabetic retinopathy and the like diseases in which angiogenesis is taking a role. That is, since a novel 3-quinolin-2(1H)-ylideneindolin-2-one derivative or a salt thereof has good VEGF inhibitory action, angiogenesis inhibitory action and anti-tumor action, it is useful as ideal VEGF inhibitor, angiogenesis inhibitor and anti-tumor agent.

  提供了药物，特别是一种血管内皮生长因子（VEGF）抑制剂，它可作为固体肿瘤、糖尿病视网膜病变等疾病的治疗药物，这些疾病中血管生成起着作用。也就是说，由于一种新型的3-喹啉-2（1H）-基吲哚-2-酮衍生物或其盐具有良好的VEGF抑制作用、血管生成抑制作用和抗肿瘤作用，因此它可作为理想的VEGF抑制剂、血管生成抑制剂和抗肿瘤药剂。