7-[2-(tetrahydro-2H-2-pyranyloxy)ethoxy]-2H-2-chromenone | 201813-16-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[2-(tetrahydro-2H-2-pyranyloxy)ethoxy]-2H-2-chromenone
• 英文别名: 7-[2-(oxan-2-yloxy)ethoxy]chromen-2-one
• CAS: 201813-16-3
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.316
• InChiKey: MFQKQHLZEWISSY-UHFFFAOYSA-N

物化性质

• 沸点：
  483.0±45.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.72
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  57.9
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  7-[2-(tetrahydro-2H-2-pyranyloxy)ethoxy]-2H-2-chromenone 在 4-甲基苯磺酸吡啶 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 以100%的产率得到7-(2-羟基乙氧基)香豆素
  参考文献：
  名称：

  Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms

  摘要：

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10324-6
• 作为产物：
  描述：

  2-(2-溴乙氧基)四氢吡喃 、 7-羟基香豆素 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以99%的产率得到7-[2-(tetrahydro-2H-2-pyranyloxy)ethoxy]-2H-2-chromenone
  参考文献：
  名称：

  Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms

  摘要：

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(97)10324-6

文献信息

• Conjugate addition of amino acid side chains to dyes containing alkynone, alkynoic ester and alkynoic amide linker arms
  作者：Geoffrey T. Crisp、Michael J. Millan

  DOI：10.1016/s0040-4020(97)10324-6

  日期：1998.1

  Derivatives of fluorescein, 7-hydroxycoumarin, Sudan 1 and dansyl chloride with linker arms containing a conjugated terminal alkyne have been prepared. The Michael addition of the sulfanyl group of protected cysteine, the hydroxyl group of protected serine and the E-amino group of protected lysine to the conjugated alkyne gave the expected heterosubstituted vinyl producs. (C) 1997 Elsevier Science Ltd. All rights reserved.