1-(4-Ethoxy-benzyl)-2,3,4,5-tetramethoxy-6-methyl-benzene | 842162-35-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Ethoxy-benzyl)-2,3,4,5-tetramethoxy-6-methyl-benzene
• 英文别名: 1-[(4-Ethoxyphenyl)methyl]-2,3,4,5-tetramethoxy-6-methylbenzene；1-[(4-ethoxyphenyl)methyl]-2,3,4,5-tetramethoxy-6-methylbenzene
• CAS: 842162-35-0
• 化学式: C₂₀H₂₆O₅
• 分子量: 346.423
• InChiKey: FJEZQQDZXIMYHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(4-Ethoxy-benzyl)-2,3,4,5-tetramethoxy-6-methyl-benzene 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 生成 2-(4-Ethoxy-benzyl)-5,6-dimethoxy-3-methyl-[1,4]benzoquinone
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029
• 作为产物：
  描述：

  2,3,4,5-四甲氧基甲苯 在 palladium on activated charcoal 盐酸 、 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成 1-(4-Ethoxy-benzyl)-2,3,4,5-tetramethoxy-6-methyl-benzene
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029

文献信息

• 2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity
  作者：Young-Sik Jung、Bo-Young Joe、Sung Ju Cho、Yasuo Konishi

  DOI：10.1016/j.bmcl.2004.12.029

  日期：2005.2

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.