methyl 3-[(4-methoxyphenethyl)amino]-propionate | 88655-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 3-[(4-methoxyphenethyl)amino]-propionate
• 英文别名: methyl 3-[2-(4-methoxyphenyl)ethylamino]propanoate
• CAS: 88655-07-6
• 化学式: C₁₃H₁₉NO₃
• mdl: MFCD11651268
• 分子量: 237.299
• InChiKey: XRHRNWGDADMWFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 3-[(4-methoxyphenethyl)amino]-propionate 在 palladium on activated charcoal 、 甲酸铵 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 methyl 3-[(4-methoxyphenethyl)-(4-aminobenzenesulfonyl)-amino]-propionate
  参考文献：
  名称：

  Design and synthesis of procollagen C-proteinase inhibitors

  摘要：

  Non-peptidic inhibitors of procollagen C-proteinase (PCP) were designed from substrate leads. Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties. Compounds 89 and 60 have IC50 values of 10 and 80 nM, respectively, against PCP; excellent selectivity over MMP's 1, 2, and 9; and activity in cell-based collagen deposition assays. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.067
• 作为产物：
  描述：

  2-(4-甲氧苯基)乙胺 、 丙烯酸甲酯（MA） 以 甲醇 为溶剂， 反应 72.0h， 以to give methyl 3-[(4-methoxyphenethyl)amino]-propionate (16.2 g)的产率得到methyl 3-[(4-methoxyphenethyl)amino]-propionate
  参考文献：
  名称：

  N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production

  摘要：

  本发明涉及一种新型有机分子类别，能够抑制C-蛋白酶，并利用它们来调节、调节和/或抑制异常胶原形成，作为治疗纤维化疾病的治疗方法。

  公开号：

  US06506936B1

文献信息

• N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of c-proteinase and for treating or preventing disorders related to unregulated collagen production
  申请人：FibroGen, Inc.

  公开号：US06506936B1

  公开（公告）日：2003-01-14

  The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders.

  本发明涉及一类新型有机分子，能够抑制C蛋白酶，并且利用它们来调节、调控和/或抑制异常胶原形成，作为治疗纤维化疾病的治疗方法。
• N-substituted arylsulfonylamino hydroxamic acids useful as inhibitors of C-proteinase and for treating or preventing disorders related to unregulated collagen production
  申请人：——

  公开号：US20030191309A1

  公开（公告）日：2003-10-09

  The present invention relates to a novel class of organic molecules capable of inhibiting C-proteinase, and to their use to regulate, modulate and/or inhibit abnormal collagen formation as a therapeutic approach towards the treatment of fibrotic disorders.

  本发明涉及一种新型有机分子类，能够抑制C-蛋白酶，并且利用它们来调节、调节和/或抑制异常胶原形成，作为治疗纤维化疾病的治疗方法。
• Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa
  作者：Thomas E. Renau、Roger Léger、Rose Yen、Miles W. She、Eric M. Flamme、Joan Sangalang、Carla L. Gannon、Suzanne Chamberland、Olga Lomovskaya、Ving J. Lee

  DOI：10.1016/s0960-894x(02)00006-9

  日期：2002.3

  Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomonas aeruginosa. A number of the new analogues were as active or more active than the lead. demonstrating that a peptide backbone is not essential for activity. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Pyrimidines LIX. Synthesis and biological properties of N-substituted dihydrouracils and dihydrothiouracils
  作者：M. A. Kaldrikyan、V. A. Geboyan、G. M. Stepanyan、B. T. Garibdzhanyan、R. V. Paronikyan、Yu. Z. Ter-Zakharyan、L. G. Akopyan、G. M. Paronikyan

  DOI：10.1007/bf00765024

  日期：1983.10
• N-ACYLPIPERIDINYLCARBONYLAMINOCARBOXYLIC ACIDS AND THEIR USE AS GLYCOPROTEIN IIB/IIa ANTAGONISTS AND FIBRINOGEN-BLOOD PLATELETS BINDING INHIBITORS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0869944A1

  公开（公告）日：1998-10-14