This invention relates to compounds of the formula: ##STR1## wherein R is an electron withdrawing group; R.sub.1 is H or COZ; X.sub.1 and X.sub.2 are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or R and X.sub.1 taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and Z is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.
本发明涉及式子如下的化合物:##STR1## 其中R是电子提取基团;R.sub.1是H或COZ;X.sub.1和X.sub.2独立地是H、低碳基、芳基、芳基低碳基或聚
苯乙烯或R和X.sub.1与它们附着的碳原子结合形成含有4至15个环状碳原子的环,可以包含高达2个杂原子,其中杂原子是O、S或N;Z是
氨基酸残基、肽残基或离去基。本发明的化合物可适用于肽合成中有用的
氨基组分的阻断或保护。本发明还涉及一种在改变分子的另一部分时保护有机分子的
氨基的方法。