(S)-6-tert-btuyl 1-methyl 2-oxo-4-(2-phenylacetamido)hexanedioate | 1171098-48-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-6-tert-btuyl 1-methyl 2-oxo-4-(2-phenylacetamido)hexanedioate
• 英文别名: 6-O-tert-butyl 1-O-methyl (4S)-2-oxo-4-[(2-phenylacetyl)amino]hexanedioate
• CAS: 1171098-48-8
• 化学式: C₁₉H₂₅NO₆
• 分子量: 363.411
• InChiKey: RWBOKVYVEDOFIX-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  98.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S,5S)-methyl -3-[2-(tert-butoxycarbonyl)ethyl]-5-methoxyisoxazolidine-5-carboxylate 、 苯丙酮酸 以 叔丁醇 为溶剂， 反应 13.0h， 以75%的产率得到(S)-6-tert-btuyl 1-methyl 2-oxo-4-(2-phenylacetamido)hexanedioate
  参考文献：
  名称：

  Synthesis of an enantiopure isoxazolidine monomer for β3-aspartic acid in chemoselective β-oligopeptide synthesis

  摘要：

  The synthesis of an enantiopure isoxazolidine monomer for the incorporation of beta(3)-aspartic acid residues into beta(3)-oligopeptides via chemoselective alpha-ketoacid-hydroxylamine amide formation is disclosed. This route involves nitrone cycloaddition of 3-thiophenylpropanal and Circumvents limitations of other potential starting Materials. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.045

文献信息

• Synthesis of an enantiopure isoxazolidine monomer for β3-aspartic acid in chemoselective β-oligopeptide synthesis
  作者：Hiroshi Ishida、Nancy Carrillo、Jeffrey W. Bode

  DOI：10.1016/j.tetlet.2009.02.045

  日期：2009.7

  The synthesis of an enantiopure isoxazolidine monomer for the incorporation of beta(3)-aspartic acid residues into beta(3)-oligopeptides via chemoselective alpha-ketoacid-hydroxylamine amide formation is disclosed. This route involves nitrone cycloaddition of 3-thiophenylpropanal and Circumvents limitations of other potential starting Materials. (C) 2009 Elsevier Ltd. All rights reserved.