1-phenyl-4,5-dibutyl-2,3-dihydro-1H-phosphole 1-sulfide | 1259008-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-phenyl-4,5-dibutyl-2,3-dihydro-1H-phosphole 1-sulfide
• 英文别名: 2,3-dibutyl-1-phenyl-4,5-dihydrophosphole sulfide；2,3-dibutyl-1-phenylphosphol-2-ene 1-sulfide；4,5-Dibutyl-1-phenyl-1-sulfido-2,3-dihydrophosphol-1-ium；4,5-dibutyl-1-phenyl-1-sulfido-2,3-dihydrophosphol-1-ium
• CAS: 1259008-76-8
• 化学式: C₁₈H₂₇PS
• 分子量: 306.452
• InChiKey: CFFOPALXIODTBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-phenyl-4,5-dibutyl-2,3-dihydro-1H-phosphole 1-sulfide 、 5,11,17,23-tetra[O-(4,4'-dimethoxytrityl)glycolyl]amino-25,26,27-tripropoxy-28-(hydroxyethoxy)-calix[4]arene 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以131 mg的产率得到
  参考文献：
  名称：

  Polymer supported calixarene derivative useful for solid-phase synthesis application

  摘要：

  A calix[4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.082
• 作为产物：
  描述：

  5-癸炔 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 二氯二茂锆 作用下， 以 甲苯 为溶剂， 反应 0.5h， 生成 1-phenyl-4,5-dibutyl-2,3-dihydro-1H-phosphole 1-sulfide
  参考文献：
  名称：

  Targeted synthesis of 2,3-disubstituted 2-phospholenes using catalytic cycloalumination of acetylenes

  摘要：

  A preparative one-pot method for the synthesis of 2,3-dialkyl-substituted phosphol-2-enes by catalytic cycloalumination of symmetric acetylenes with AlEt3 catalyzed by Cp2ZrCl2 is developed. The reaction gives the corresponding aluminacyclopentenes, which then react in situ with phosphorus dihalides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.029

文献信息

• Preparation of 2-phospholene derivatives from zirconacyclopentenes
  作者：Yiqing Zhou、Xiaoyu Yan、Chanjuan Xi

  DOI：10.1016/j.tetlet.2010.09.061

  日期：2010.11

  Zirconacyclopentenes, which are easily prepared from alkynes, alkenes, and zirconocene compounds, reacted with dichlorophenylphosphine to give 2-phospholene in high yields. The reaction was performed conveniently in one-pot from an alkyne, alkene, dichlorophosphine, and zirconocene compounds. (C) 2010 Elsevier Ltd. All rights reserved.
• Targeted synthesis of 2,3-disubstituted 2-phospholenes using catalytic cycloalumination of acetylenes
  作者：Vladimir A. D’yakonov、Alevtina L. Makhamatkhanova、Rina A. Agliullina、Tat’yana V. Tyumkina、Usein M. Dzhemilev

  DOI：10.1016/j.tetlet.2014.05.029

  日期：2014.7

  A preparative one-pot method for the synthesis of 2,3-dialkyl-substituted phosphol-2-enes by catalytic cycloalumination of symmetric acetylenes with AlEt3 catalyzed by Cp2ZrCl2 is developed. The reaction gives the corresponding aluminacyclopentenes, which then react in situ with phosphorus dihalides. (C) 2014 Elsevier Ltd. All rights reserved.
• Polymer supported calixarene derivative useful for solid-phase synthesis application
  作者：Giuseppe Granata、Grazia M.L. Consoli、Sebastiano Sciuto、Corrada Geraci

  DOI：10.1016/j.tetlet.2010.09.082

  日期：2010.11

  A calix[4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton. (C) 2010 Elsevier Ltd. All rights reserved.