4-n-dodecylpyridine | 59936-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-n-dodecylpyridine
• 英文别名: 4-Dodecylpyridine
• CAS: 59936-36-6
• 化学式: C₁₇H₂₉N
• 分子量: 247.424
• InChiKey: FVZKYRYEWBZUTR-UHFFFAOYSA-N

物化性质

• 熔点：
  1 °C
• 沸点：
  186 °C(Press: 9 Torr)
• 密度：
  0.8867 g/cm3(Temp: 14 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-n-dodecylpyridine 在 氢溴酸 作用下， 以 乙醚 、 水 为溶剂， 反应 0.25h， 生成 4-n-dodecylpyridinium hydrobromide
  参考文献：
  名称：

  一些单链和双链吡啶鎓两亲物的热致液晶行为

  摘要：

  DOI：

  10.1021/j100207a035
• 作为产物：
  描述：

  1,1,5,5-tetraethoxy-3-dodecyl-3-pentanol 在 乙酸铵 作用下， 以 溶剂黄146 为溶剂， 以39%的产率得到4-n-dodecylpyridine
  参考文献：
  名称：

  酮缩醛的化学：II。β，β'-酮二缩醛和β，β'-羟基二缩醛与氨和胺反应

  摘要：

  β，β′-Ketodiacetal 和 β，β′-hydroxydiacetals 与乙酸铵在乙酸中反应生成取代的吡啶，与芳香胺在盐酸存在下反应生成取代的五甲胺盐。

  DOI：

  10.1007/s11178-005-0303-y

文献信息

• PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE
  申请人：Okamoto Kuniaki

  公开号：US20120130107A1

  公开（公告）日：2012-05-24

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R 1 's and T are as described in claim 1 ) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R 3 to R 5 are as described in claim 1 ), and a disulfonic acid ester represented by a general formula [1′] (in the formula, two R 16 's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5).

  提供一种高效生产双季铵盐和其新型合成中间体的方法。本发明涉及一种生产由通用式[3]表示的双季铵盐的方法，包括将由通用式[1]表示的二磺酸酯（在该式中，两个R1和T的定义如权利要求1中所述）与由通用式[2]表示的三级胺（在该式中，R3到R5的定义如权利要求1中所述）以及由通用式[1']表示的二磺酸酯（在该式中，两个R16独立表示卤原子或C1-C3氟烷基，两个m独立表示1至5的整数）反应。
• Cobalt-Catalyzed C4-Selective Direct Alkylation of Pyridines
  作者：Takashi Andou、Yutaka Saga、Hirotomo Komai、Shigeki Matsunaga、Motomu Kanai

  DOI：10.1002/anie.201208666

  日期：2013.3.11

  How pyridine got its tail: A new catalyst for the atom‐economical C4‐selective direct alkylation of pyridines is described. A combination of CoBr2 and LiBEt3H catalyzes the reaction of pyridines with 1‐alkenes at 70 °C to give alkylation products with C4/C2 ratios of >20:1. Substrate/catalyst ratios of up to 4000, and a turnover number of 3440 were achieved.

  吡啶是如何产生尾巴的：描述了一种用于原子经济的吡啶的C4选择性直接烷基化的新催化剂。CoBr 2和LiBEt 3 H的组合可在70°C催化吡啶与1-烯烃的反应，得到C4 / C2比> 20：1的烷基化产物。底物/催化剂的比例高达4000，周转数达到3440。
• IONIC LIQUID CONTAINING ALLYLSULFONATE ANION
  申请人：Watahiki Tsutomu

  公开号：US20120157680A1

  公开（公告）日：2012-06-21

  PROBLEM: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. MEANS FOR SOLVING THE PROBLEM: The present invention is the invention of the ionic liquid represented by the general formula [1]: wherein, R 1 to R 3 and n pieces of R 4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R 5 to R 7 each independently represent alkyl group, aralkyl group, or aryl group, R 8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R 1 to R 7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R 3 and R 4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R 5 to R 7 or R 5 to R 6 may form hetero ring with nitrogen atom binding thereto}.

  问题：提供一种新型离子液体，成本低、环保，并具有低粘度和熔点。 解决问题的方法：本发明是一种由通式[1]表示的离子液体的发明：其中，R1到R3和n个R4分别独立表示氢原子或具有1到4个碳原子的烷基基团，R5到R7分别独立表示烷基基团、芳基烷基基团或芳基基团，R8表示烷基基团、芳基烷基基团、芳基基团或由通式[2]表示的基团：（其中T表示具有1到8个碳原子的烷基链，n表示1或2，R1到R7与上述相同），X表示氮原子或磷原子，n表示1或2。当n为1时，R3和R4结合并且可能与相邻碳原子一起形成环己烯环。此外，当X为氮原子时，R5到R7或R5到R6可能与结合在一起的氮原子形成杂环}。
• An investigation of factors governing conformational disorder of hydrocarbon chains in the solid state
  作者：M.J.M. Van Oort、G. Neshvad、M.A. White

  DOI：10.1016/0022-4596(87)90020-x

  日期：1987.7

  factors which govern conformational disorder of the n-alkyl chains in the solid state. Many of the compounds prepared displayed solid-solid phase transitions, but the thermodynamic quantities measured suggest that the bonding and structural features of these complexes control the reversibility and limit the extent of conformational disorder of the hydrocarbon chains in the solid state.

  制备了两种过渡金属配合物，双（二正烷基铵）四氯金属酸盐和双（正烷基吡啶）二氯金属盐，并通过差示扫描量热法进行了研究。进行这项研究是为了研究控制固态正烷基链构象障碍的因素。制备的许多化合物都显示出固-固相变，但测得的热力学量表明，这些配合物的键合和结构特征控制着可逆性，并限制了固态烃链的构象无序程度。
• Transport vehicles for macromolecules
  申请人：Stitching Voor DeTechnische Wetenschappen

  公开号：US05853694A1

  公开（公告）日：1998-12-29

  The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles. ##STR1##

  该发明涉及一种具有一般式I的新化合物，用作将大分子引入细胞的工具。该发明还涉及一种将大分子引入细胞的组合物，其中包括由至少一种化合物在溶剂中形成的囊泡。大分子可以被并入囊泡中和/或结合到囊泡或其他新化合物的聚集体上。在优选实施例中，至少一个靶向分子，例如（标记的）抗体，还可以附加到囊泡上。 ##STR1##