2-[1-(环氧乙烷-2-基甲氧基)乙氧基甲基]环氧乙烷 | 3775-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 中文名称: 2-[1-(环氧乙烷-2-基甲氧基)乙氧基甲基]环氧乙烷
• 英文名称: Acetaldehyde bis(2,3-epoxypropyl)acetal
• 英文别名: 2-[1-(oxiran-2-ylmethoxy)ethoxymethyl]oxirane
• CAS: 3775-84-6
• 化学式: C₈H₁₄O₄
• 分子量: 174.19
• InChiKey: MIQWTCWXRZROTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.5
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2910900090

文献信息

• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。
• Magnesium-Containing Polymers for the Treatment of Hyperphosphatemia
  申请人：Huval Chad C.

  公开号：US20090162314A1

  公开（公告）日：2009-06-25

  A pharmaceutical composition comprising an aliphatic amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable magnesium compound comprising a magnesium ion is disclosed. A method of treating hyperphosphatemia in a patient is also disclosed. The method comprises the step of administering to the subject an effective amount of the disclosed pharmaceutical composition.

  本发明公开了一种包括脂肪族胺聚合物或其药学上可接受的盐，以及含有镁离子的药学上可接受的镁化合物的药物组合物。还公开了一种治疗患者高磷血症的方法。该方法包括向受试者投与所述药物组合物的有效量的步骤。
• Poly(diallylamine)-based bile acid sequestrants
  申请人：Genzyme Corporation

  公开号：US20040151687A1

  公开（公告）日：2004-08-05

  The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C 3 -C 24 -alkyl group, an aralkyl group or an aryl group.

  本发明涉及一种从患者中去除胆汁酸的方法以及在该方法中使用的某些聚合物。该方法包括向患者投与治疗有效量的聚合物组合物，该组合物包括一种取代了疏水基团的聚（二烯丙胺）聚合物。疏水基团可以是取代或未取代的直链或支链C3-C24烷基，芳基烷基或芳基。
• HYPERPHOSPHATEMIA IN DOMESTIC ANIMALS: COMPOSITIONS AND METHODS OF TREATMENT
  申请人：Wren Allison

  公开号：US20080069860A1

  公开（公告）日：2008-03-20

  The present invention is generally related to the treatment of hyperphosphatemia in domestic animals. It is specifically directed to compositions containing phosphate binders that are palatable to domestic animals and methods using such compositions. In a composition aspect, the present invention provides a composition that includes: a rare earth compound (e.g., lanthanum oxycarbonate or lanthanum carbonate hydroxide), calcium salts (e.g, calcium carbonate or calcium acetate), aluminum salts (e.g., aluminum hydroxide or a hydrophilic exchange resin; and an ingredient of domestic animal food, wherein the ingredient is selected from a group consisting of chicken, beef, lamb, chicken meal or lamb meal, corn, rice, bone meal, fish meal, fish, egg product, beef, beef meal, corn gluten meal, poultry by-product meal, wheat flour, beef tallow, maple syrup, honey, apple, flaxseed, flaxseed meal, rice bran and germ, oats, barley, and wheat bran.

  本发明通常涉及治疗家畜高磷血症。具体而言，本发明涉及含有对家畜具有食欲的磷酸盐结合剂的组合物以及使用此类组合物的方法。在组合物方面，本发明提供一种包括以下成分的组合物：稀土化合物（例如，氧化碳酸镧或碳酸氢镧），钙盐（例如，碳酸钙或醋酸钙），铝盐（例如，氢氧化铝或亲水性交换树脂）以及家畜食品成分，其中所述成分选自以下组合：鸡肉、牛肉、羊肉、鸡肉粉或羊肉粉、玉米、米、骨粉、鱼粉、鱼、蛋制品、牛肉、牛肉粉、玉米麸粉、家禽副产品粉、小麦粉、牛油、枫糖浆、蜂蜜、苹果、亚麻籽、亚麻籽粉、米糠和胚芽、燕麦、大麦和麦麸。
• Anion-binding polymers and uses thereof
  申请人：Connor Eric

  公开号：US20050147580A1

  公开（公告）日：2005-07-07

  Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.

  本文描述了一种阴离子结合聚合物。在某些情况下，这些阴离子结合聚合物是低肿胀的阴离子结合聚合物。在某些情况下，这些阴离子结合聚合物具有孔体积分布，使得聚合物的一部分在目标离子的分子量超过某个百分比时不可用于非相互作用的溶质。在某些情况下，这些阴离子结合聚合物的特点是低离子结合干扰，其中干扰是相对于非干扰缓冲液在例如胃肠模拟液中测量的。还描述了制药组合物、使用方法和套件。