Natrium-N-methyl-N-phenyldithiocarbamat | 83559-31-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Natrium-N-methyl-N-phenyldithiocarbamat
• 英文别名: potassium N-methyl-N-phenyl-dithiocarbamate；potassium methyl(phenyl)carbamodithioate；potassium;N-methyl-N-phenylcarbamodithioate
• CAS: 83559-31-3
• 化学式: C₈H₈NS₂*K
• 分子量: 221.389
• InChiKey: HCZVQTYRBBWEAN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.04
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Natrium-N-methyl-N-phenyldithiocarbamat 在 盐酸 、 sodium nitrite 作用下， 以 甲醇 、 水 为溶剂， 生成 二(甲基苯硫基氨基甲酰)二硫醚
  参考文献：
  名称：

  Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

  摘要：

  Monoglyceride lipase (MGL) inhibition may offer an approach in treating diseases in which higher 2-arachidonoyglycerol activity would be beneficial. We report here the synthesis and pharmacological evaluation of bis(dialkylaminethiocarbonyl)disulfide derivatives as irreversible MGL inhibitors. Inhibition occurs through interactions with MGL C208 and C242 residues, and these derivatives exhibit high inhibition selectivity over fatty acid amide hydrolase, another endocannabinoid-hydrolyzing enzyme.

  DOI：

  10.1021/jm901323s
• 作为产物：
  描述：

  二硫化碳 、 N-甲基苯胺 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 4.0h， 生成 Natrium-N-methyl-N-phenyldithiocarbamat
  参考文献：
  名称：

  使用二硫代氨基甲酸盐进行位点特异性分子内 C−H 官能化的通用方法

  摘要：

  分子内氢原子转移是未活化的脂肪族 C−H 键位点特异性功能化的既定方法。使用这种策略的转化通常需要使用强氧化剂形成不稳定的中间体，并且主要针对 CH 卤化或分子内胺化。在此，我们报告了一种位点特异性的 C−H 官能化，它显着增加了通过分子内氢原子转移进行的反应的合成范围和收敛性。稳定、可分离的N-二硫代氨基甲酸酯可用作通过光或自由基引发形成的酰胺自由基的前体，以在各种复杂结构中有效地传递高度通用的烷基二硫代氨基甲酸酯。

  DOI：

  10.1002/anie.201806963

文献信息

• Multicomponent synthesis of di-aryl dithiocarbamates <i>via</i> electron donor–acceptor photoactivation with thianthrenium salts
  作者：Min Liu、Yong Qian、Yanqi Wu、Fengzhi Zhang

  DOI：10.1039/d3gc00336a

  日期：——

  and alkyl amines without adding any photocatalysts, transition-metal catalysts, or ligands. A novel photoactivated electron donor–acceptor complex was proposed as the key intermediate. This protocol offers a new approach towards di-aryl dithiocarbamates, thus promising their potential applications in pharmaceutical chemistry and sulfur chemistry.

  在此，从现成的噻蒽盐中有效地开发了一种用于生成二芳基二硫代氨基甲酸酯的多组分、环境友好的方案。使用芳香胺和烷基胺均可顺利进行反应，无需添加任何光催化剂、过渡金属催化剂或配体。提出了一种新型光活化电子供体-受体复合物作为关键中间体。该协议为二芳基二硫代氨基甲酸酯提供了一种新方法，从而有望在药物化学和硫化学中发挥潜在应用。
• Crystalline polyolefin composition
  申请人：Chisso Corporation

  公开号：EP0416321A1

  公开（公告）日：1991-03-13

  A crystalline polyolefin composition which provides molded articles having improved stiffness characteristics is disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I): wherein R represents an alkylidene group having from 1 to 4 carbon atoms or a sulfur atom; Ar1 and Ar2, which may be the same or different, each represents an alkylarylene group or a cycloalkylarylene group; and n represents 0 or 1, and (B) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with lithium or sodium, (2) a dithiocarbamic acid salt with lithium, sodium or potassium, (3) a 2-mercaptobenzothiazole salt with lithium, sodium or potassium, (4) a 2-mercaptobenzimidazole salt with lithium, sodium or potassium and (5) a benzotriazole salt with lithium, sodium or potassium. A crystalline polyolefin composition which provides molded articles having improved stiffness charateristics is also disclosed, comprising 100 parts by weight of a crystalline polyolefin, (A) from 0.001 to 1 part by weight of a fluorophosphite compound represented by formula (I) shown above, (B ) from 0.001 to 1 part by weight of at least one compound selected from the group consisting of (1) an aliphatic monocarboxylic acid salt with potassium, strontium or barium, (2) a hydroxy-higher fatty acid salt with potassium, strontium or barium, (3) an aliphatic polycarboxylic acid salt with lithium, sodium, potassium, strontium or barium, (4) a salt of an aliphatic hydroxy acid having form 2 to 6 carbon atoms with lithium, sodium, potassium, magnesium, strontium or barium, (5) an aromatic carboxylic acid salt with lithium, sodium, strontium, barium or aluminum, (6) a glutamic acid salt with lithium, sodium, potassium, strontium or barium, (7) an aliphatic phosphoric acid salt with sodium, potassium, calcium, strontium or barium, (8) a lithium, sodium, potassium or barium salt of a cyclic phosphorus compound represented by formula (II): wherein Ar3 and Ar4, which may be the same or different, each represents an arylene group, an alkylarylene group, a cycloalkylarylene group, an arylarylene group or an aralkylarylene group; M represents lithium, sodium, potassium or barium; and m represents an atomic valence of M, (9) magnesium or aluminum hydroxide, (10) magnesium oxide, (11) magnesium or calcium carbonate and (12) hydrotalcite, and (C) from 0.01 to 1 part by weight of an aliphatic amine.

  本发明公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，该组合物包括按重量计100份的结晶聚烯烃、(A)按重量计0.001至1份的由式(I)代表的亚磷酸氟化合物： 其中 R 代表具有 1 至 4 个碳原子的亚烷基或硫原子；Ar1 和 Ar2 可以相同或不同，各自代表烷基芳基或环烷基芳基；n 代表 0 或 1，以及 (B) 0.(1) 锂或钠的脂肪族一羧酸盐，(2) 锂、钠或钾的二硫代氨基甲酸盐、(3) 锂、钠或钾的 2-巯基苯并噻唑盐， (4) 锂、钠或钾的 2-巯基苯并咪唑盐， (5) 锂、钠或钾的苯并三唑盐。 本发明还公开了一种结晶聚烯烃组合物，该组合物可提供具有改进的刚度特性的模塑制品，其成分包括 100 份（重量）结晶聚烯烃、(A) 0.001 至 1 份（重量）由上文式(I)代表的亚磷酸氟化合物、(B ) 0.(1)钾、锶或钡的脂肪族一羧酸盐；(2)钾、锶或钡的羟基高级脂肪酸盐；(3)锂、钠、钾、锶或钡的脂肪族多羧酸盐；(4)锂、钠、钾、镁、锶或钡的具有 2 至 6 个碳原子的脂肪族羟基酸盐、(5) 锂、钠、锶、钡或铝的芳香族羧酸盐； (6) 锂、钠、钾、锶或钡的谷氨酸盐、(7) 含有钠、钾、钙、锶或钡的脂肪族磷酸盐， (8) 由式（II）代表的环磷化合物的锂、钠、钾或钡盐： 其中 Ar3 和 Ar4 可以相同或不同，各自代表芳基、烷芳基、环烷芳基、芳基芳基或芳基芳基；M 代表锂、钠、钾或钡；m 代表 M 的原子价，(9) 氢氧化镁或铝，(10) 氧化镁，(11) 碳酸镁或碳酸钙和 (12) 水滑石，以及 (C) 0.01至1份重量的脂肪族胺。
• Farghaly; Moharram, Bollettino Chimico Farmaceutico, 1999, vol. 138, # 6, p. 280 - 289
  作者：Farghaly、Moharram

  DOI：——

  日期：——
• Ried, Walter; Vogl, Manfred; Knorr, Harald, Liebigs Annalen der Chemie, 1982, # 3, p. 396 - 405
  作者：Ried, Walter、Vogl, Manfred、Knorr, Harald

  DOI：——

  日期：——
• Synthesis, Characterization and In-vitro Antifungal Evaluation of Some Dithiocarbamic Acid Derivatives
  作者：N.M. Mahfouz、A.M. Moharram

  DOI：10.1211/146080899128734901

  日期：1999.5.1