1-[(3-hydroxypropyl)amino]-9,10-anthracenedione | 62956-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-[(3-hydroxypropyl)amino]-9,10-anthracenedione
• 英文别名: 1-(γ-Hydroxypropylamino)anthrachinon；1-[(3-Hydroxypropyl)amino]anthracene-9,10-dione；1-(3-hydroxypropylamino)anthracene-9,10-dione
• CAS: 62956-45-0
• 化学式: C₁₇H₁₅NO₃
• mdl: MFCD01029130
• 分子量: 281.311
• InChiKey: UATCOPKQRIWTHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[(3-hydroxypropyl)amino]-9,10-anthracenedione 在 吡啶 作用下， 以 氯仿 为溶剂， 反应 27.0h， 生成 1-<<3-<<2-<(2-hydroxyethyl)amino>ethyl>amino>propyl>amino>anthraquinone
  参考文献：
  名称：

  一系列与蒽醌嵌入剂连接的顺式-PtCl2复合物的制备，表征和抗癌活性。

  摘要：

  一系列新的顺式-PtL2X2型配合物[其中L是单齿AQ-Y（CH2）nNH2，L2是双齿AQ-Y（CH2）nNH（CH2）2NH2；AQ =蒽醌，X = Cl，I，Y = NH，O]，其中蒽醌嵌入剂通过（氨基烷基）氨基，（氧基烷基）氨基或聚乙二醇（氨基乙基）氨基连接链束缚在顺式PtCl2单元上制备并体外筛选抗P388白血病。对选定的复合物进行了体内毒性研究。通过元素分析，195Pt NMR光谱和FTIR对所有配合物进行表征。1：1 Pt-嵌入剂复合物显示出比1：2 Pt-嵌入剂复合物更高的体外细胞毒性活性。二氯化物配合物始终比二碘化物对应物更具活性。在1：具有较短连接链（n = 2、3）的1 Pt-嵌入剂复合物表现出最高的细胞毒活性。三种化合物，[[[2-[[2-（蒽醌-1-基氨基）乙基]氨基]乙基]胺-N，N']二氯铂（II），[[2-[[3-（蒽醌-1-基氨基） ）丙基]氨基]乙基]胺

  DOI：

  10.1021/jm00105a063
• 作为产物：
  描述：

  氨基-9,10-蒽二酮 在 copper(I) bromide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 1-[(3-hydroxypropyl)amino]-9,10-anthracenedione
  参考文献：
  名称：

  卤代蒽醌衍生物与胺在质子惰性溶剂中的乌尔曼缩合反应

  摘要：

  在非质子介质中卤代蒽醌与胺的乌尔曼缩合反应中，亚铜催化剂比铜催化剂更有效。在 Cu(I) 催化剂存在下，具有羟基的胺（3-氨基-1-丙醇和 2-氨基乙醇）比碱性更高的丁胺更具反应性。

  DOI：

  10.1246/bcsj.50.547

文献信息

• Anti-cancer agents
  申请人：——

  公开号：US20030203975A1

  公开（公告）日：2003-10-30

  A compound is provided having the formula: 1 wherein R 1 and R 2 are independently hydrogen, hydroxy, alkoxy or acyloxy R 3 and R 4 are independently oxo, hydroxy or hydrogen; one of R 5 or R 6 is -A-B and the other is hydrogen, hydroxy, alkoxy, acyloxy, a group -A-B or a group -amino-R 7 —O—Y; the or each A is independently a spacer group having the formula -amino-R 7 —O— which is bonded to the anthracene ring via the amino group nitrogen and to B via the —O— atom R 7 is a divalent organic radical; B is an amino acid residue, a peptide group, or isostere thereof; and Y is hydrogen or a capping group, or a physiologically acceptable derivative thereof. The compounds primarily have utility against cancers, but also have use against viruses and parasites having topoisomerases.

  提供一种化合物，其化学式为：其中R1和R2分别为氢、羟基、烷氧基或酰氧基；R3和R4分别为酮基、羟基或氢；R5或R6中的一个为-A-B，另一个为氢、羟基、烷氧基、酰氧基、-A-B基团或-氨基-R7-O-Y基团；每个A独立地为具有化学式-amino-R7-O-的间隔基团，通过氨基氮原子与蒽环结合，并通过-O-原子与B结合；R7为二价有机基团；B为氨基酸残基、肽基团或其同分异构体；Y为氢或封端基团，或其生理上可接受的衍生物。这些化合物主要用于治疗癌症，同时也可用于治疗具有拓扑异构酶的病毒和寄生虫。
• Liquid toners with hydrocarbon solvents
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0706095A1

  公开（公告）日：1996-04-10

  Polymeric dyes that comprise (a) segments that render the dyes soluble or dispersible in hydrocarbon solvents and (b) segments that impart color. The polymeric dyes can be introduced into hydrocarbon solvents or formed in hydrocarbon solvents to form stable colored dispersions, which can be used as toners for electrophotography. In these toners, the polymeric dye contains macromeric moieties that render the polymeric dye dispersible in hydrocarbon solvents. The polymeric dye may contain either a charge-directing chelating moiety or a surface-release promoting moiety or both of these moieties.

  聚合染料由(a)使染料在烃类溶剂中可溶或可分散的片段和(b)赋予颜色的片段组成。聚合染料可以引入到烃类溶剂中或在烃类溶剂中形成稳定的有色分散液，可用作电子摄影的色调剂。在这些色调剂中，聚合染料包含使聚合染料在烃类溶剂中分散的大分子基团。聚合染料可以包含电荷引导螯合基团或表面释放促进基团或这两种基团。
• Curable Ink Composition
  申请人：Domino Printing Sciences Plc

  公开号：US20220145109A1

  公开（公告）日：2022-05-12

  Provided is a curable ink composition, in particular a curable inkjet ink composition. The ink composition has a dye monomer, a carrier monomer and an initiator. The dye monomer has a chromophore moiety that is covalently bonded to at least one polymerizable functional group and is present at 1.0 wt % or more based on total weight of the ink composition. The carrier monomer has at least one polymerizable functional group and is present in at 50 wt % or more based on total weight of the ink composition. The ink compositions are suitable for radiation curing such as UV curing and have good cure properties or light fastness properties.

  提供的是一种可治愈的油墨组合物，特别是一种可治愈的喷墨油墨组合物。该油墨组合物具有染料单体、载体单体和引发剂。染料单体具有一种色团基团，该色团基团与至少一个可聚合的官能团共价键合，并且按照油墨组合物的总重量计算，其含量为1.0重量％或更多。载体单体具有至少一个可聚合的官能团，并且按照油墨组合物的总重量计算，其含量为50重量％或更多。该油墨组合物适用于辐射固化，如紫外线固化，并具有良好的固化性能或耐光性能。
• Reactive polymeric dyes
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0621322A1

  公开（公告）日：1994-10-26

  Reactive polymeric dyes are provided comprising a chromophoric moiety derived from at least one free radically polymerizable dye and an azlactone moiety derived from 2-alkenylazlactone such that the free radically polymerizable dye is incorporated into the backbone of the polymer. Alternatively, 2-alkenylazlactone is polymerized and then derivatized with a nucleophilic dye or dyes, such that the chromophoric portion of the dye is pendent to the polymer backbone. Both types of reactive polymeric dyes may also contain additional polymerized monomeric units. The reactive polymeric dyes of the present invention can be used in a photoresist system and in particular in a color proofing construction.

  反应性聚合染料包括由至少一种可自由基聚合的染料衍生的发色分子和由 2-烯丙基氮内酯衍生的氮内酯分子，这样可自由基聚合的染料就与聚合物的骨架结合在一起。另一种方法是将 2-烯丙基氮杂环内酯聚合，然后用一种或多种亲核染料进行衍生，使染料的发色部分悬挂在聚合物骨架上。这两类活性聚合染料还可能含有额外的聚合单体单元。本发明的活性聚合染料可用于光致抗蚀剂系统，特别是用于彩色打样结构。
• Novel anthraquinone derivatives with redox-active functional groups capable of producing free radicals by metabolism: are free radicals essential for cytotoxicity?
  作者：Dinorah Barasch、Omer Zipori、Israel Ringel、Isaac Ginsburg、Amram Samuni、Jehoshua Katzhendler

  DOI：10.1016/s0223-5234(00)80029-x

  日期：1999.7

  The mode of action of antitumour anthraquinone derivatives (i.e. mitoxantrone) is not clearly established yet. It includes, among others, intercalation and binding to DNA, bioreduction and aerobic redox cycling. A series of anthraquinone derivatives, with potentially bioreducible groups sited in the side chain, have been synthesized and biologically evaluated. Their redox and cytotoxic activities were screened. Derivatives which bear a 2-(dimethylamino)ethylamino substituent, known to confer high DNA affinity, demonstrated cytotoxicity but not redox activity (beside the anthraquinone reduction). Conversely, derivatives which showed redox activity were not cytotoxic toward the P388 cell line. The results suggest that bioreduction is not the main mode of action in the cytotoxicity of anthraquinones. (C) 1999 Editions scientifiques et medicales Elsevier SAS.