2-[3-(Dimethylamino)propylamino]anthracene-9,10-dione | 123296-24-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 2-[3-(Dimethylamino)propylamino]anthracene-9,10-dione
• CAS: 123296-24-2
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.38
• InChiKey: JABQZVCQNXJXJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯蒽醌 、 N,N-二甲基-1,3-二氨基丙烷 在 copper(II) sulfate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.25h， 以30%的产率得到2-[3-(Dimethylamino)propylamino]anthracene-9,10-dione
  参考文献：
  名称：

  Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs

  摘要：

  DOI：

  10.1016/0223-5234(89)90159-1

文献信息

• KATZHENDLER, JEHOSHUA;GEAN, KERIA-FIORELLA;BAR-AD, GIDON;TASHMA, ZEEV;BEN+, EUR. J. MED. CHEM., 24,(1989) N, C. 23-30
  作者：KATZHENDLER, JEHOSHUA、GEAN, KERIA-FIORELLA、BAR-AD, GIDON、TASHMA, ZEEV、BEN+

  DOI：——

  日期：——
• HEDGEHOG INHIBITOR ASSAY
  申请人：Toftgard Rune

  公开号：US20080115238A1

  公开（公告）日：2008-05-15

  The present invention relates to the field of Hedgehog signalling, and more specifically to a cell-based assay system and methods for identifying inhibitors and/or antagonists of specific cellular events in said signalling pathway. The present invention hereby proposes a novel approach for identifying inhibitors and/or antagonists downstream of the signalling components Smoothened and Patched, e.g. at the Gli-level. The assay comprises cells lacking a functional Sufu protein, which according to the invention is a protein component of emerging importance in the Hedgehog signalling pathway.
• [EN] HEDGEHOG INHIBITOR ASSAY<br/>[FR] DOSAGE D'INHIBITEUR HEDGEHOG
  申请人：KAROLINSKA INST INNOVATIONS AB

  公开号：WO2006080894A2

  公开（公告）日：2006-08-03

  [EN] The present invention relates to the field of Hedgehog signalling, and more specifically to a cell-based assay system and methods for identifying inhibitors and/or antagonists of specific cellular events in said signalling pathway. The present invention hereby proposes a novel approach for identifying inhibitors and/or antagonists downstream of the signalling components Smoothened and Patched, e.g. at the Gli-level. The assay comprises cells lacking a functional Sufu protein, which according to the invention is a protein component of emerging importance in the Hedgehog signalling pathway.
  [FR] La présente invention concerne le domaine de la signalisation Hedgehog, et plus particulièrement un système et des méthodes de dosage à base de cellules destinés à identifier des inhibiteurs et/ou des antogonistes d'événements cellulaires spécifiques dans la voie de signalisation. Cette invention porte sur une nouvelle approche visant à identifier des inhibiteurs et/ou des antagonistes en aval des composants de signalisation Smoothened et Patched, soit au niveau Gli. L'analyse porte sur des cellules auxquelles manque une protéine Sufu fonctionnelle laquelle, selon l'invention, est un composant protéique présentant une importance nouvelle dans la voie de signalisation Hedgehog.
• Synthesis of aminoanthraquinone derivatives and their in vitro evaluation as potential anti-cancer drugs
  作者：J KATZHENDLER、K GEAN、G BARAD、Z TASHMA、R BENSHOSHAN、I RINGEL、U BACHRACH、A RAMU

  DOI：10.1016/0223-5234(89)90159-1

  日期：1989.1