(E)-N-isopropylpent-3-enamide | 1443734-94-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-N-isopropylpent-3-enamide
• 英文别名: (E)-N-propan-2-ylpent-3-enamide
• CAS: 1443734-94-8
• 化学式: C₈H₁₅NO
• 分子量: 141.213
• InChiKey: ALLDCPWQVHLOBW-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  钾(E)-丙烯基-1-三氟硼酸 、 N-异丙基氯乙酰氨 在 XPhos Pd G2 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以91%的产率得到(E)-N-isopropylpent-3-enamide
  参考文献：
  名称：

  Pd-Catalyzed Cross-Coupling of Potassium Alkenyltrifluoroborates with 2-Chloroacetates and 2-Chloroacetamides

  摘要：

  A protocol for the stereocontrolled synthesis of (E)- and (Z)-beta,gamma-unsaturated esters and amides is reported. 2-Chloroacetates as well as secondary and tertiary 2-chloroacetamides were successfully employed as electrophiles in the Suzuki-Miyaura cross-coupling reaction with potassium (E)- and (Z)-alkenyltrifluoroborates, affording the corresponding products in high yield.

  DOI：

  10.1021/ol401377q

文献信息

• INHIBITORS OF TYROSINE KINASES AND USES THEREOF
  申请人：Jankowski D. Orion

  公开号：US20080039426A1

  公开（公告）日：2008-02-14

  Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

  本文披露了一些抑制特定酪氨酸激酶活性的化合物。本文还披露了制备这些化合物的方法。此外，还披露了包括这些化合物的药物组合物。提供了使用这些化合物，单独或与其他治疗剂联合使用，用于治疗酪氨酸激酶介导的疾病或状况或酪氨酸激酶依赖性疾病或状况的方法。
• US7625880B2
  申请人：——

  公开号：US7625880B2

  公开（公告）日：2009-12-01
• Pd-Catalyzed Cross-Coupling of Potassium Alkenyltrifluoroborates with 2-Chloroacetates and 2-Chloroacetamides
  作者：Gary A. Molander、Thiago Barcellos、Kaitlin M. Traister

  DOI：10.1021/ol401377q

  日期：2013.7.5

  A protocol for the stereocontrolled synthesis of (E)- and (Z)-beta,gamma-unsaturated esters and amides is reported. 2-Chloroacetates as well as secondary and tertiary 2-chloroacetamides were successfully employed as electrophiles in the Suzuki-Miyaura cross-coupling reaction with potassium (E)- and (Z)-alkenyltrifluoroborates, affording the corresponding products in high yield.