2-(tert-butylamino)-N-propan-2-ylacetamide | 38630-95-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(tert-butylamino)-N-propan-2-ylacetamide
• CAS: 38630-95-4
• 化学式: C₉H₂₀N₂O
• mdl: MFCD11154558
• 分子量: 172.271
• InChiKey: CRSNBAJCEKVDJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-异丙基氯乙酰氨 、 叔丁胺 以 苯 为溶剂， 生成 2-(tert-butylamino)-N-propan-2-ylacetamide
  参考文献：
  名称：

  5-Imino-2-oxo-1,2,3-oxathiazolidines

  摘要：

  DOI：

  10.1021/jo00949a005

文献信息

• Open chain alkoxyamine compounds and their use as polymerization regulators
  申请人：——

  公开号：US20030125489A1

  公开（公告）日：2003-07-03

  The invention relates to a compound of formula Ia, Ib or Ic 1 The open chain alkoxyamine compounds are useful for the polymerization of ethylenically unsaturated monomers. The compounds of the present invention provide polymeric resin products having low polydispersity. The polymerization process proceeds with enhanced monomer to polymer conversion efficiency. In particular, this invention relates to stable free radical-mediated polymerization processes which provide homopolymers, random copolymers, block copolymers, multiblock copolymers, graft copolymers and the like, at enhanced rates of polymerization and enhanced monomer to polymer conversions.

  该发明涉及公式Ia、Ib或Ic1的化合物。这些开链烷氧胺化合物对于乙烯基不饱和单体的聚合是有用的。本发明的化合物提供具有低聚分散度的聚合物树脂产品。聚合过程在单体到聚合物的转化效率上得到了提高。特别是，本发明涉及稳定的自由基介导的聚合过程，该过程提供同聚物、随机共聚物、嵌段共聚物、多嵌段共聚物、接枝共聚物等，其聚合速率和单体到聚合物的转化率得到了提高。
• 10a-Azalide Compound
  申请人：Sugimoto Tomohiro

  公开号：US20090281292A1

  公开（公告）日：2009-11-12

  [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria. [Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

  【目标】提供一种具有新结构的化合物，对流感嗜血杆菌和红霉素耐药菌（例如耐药肺炎球菌和链球菌）以及传统的红霉素敏感菌具有有效作用。 【解决方案】本发明提供了一种新型10a-氮杂环十六元化合物，其化学式为（I），其药学上可接受的盐或其溶剂化物，或其制备的中间体。该化合物对流感嗜血杆菌、红霉素耐药性肺炎球菌等具有卓越的抗菌活性，因此可以作为治疗传染病的药物。
• TLR7/8 antagonists and uses thereof
  申请人：Merck Patent GmbH

  公开号：US10399957B2

  公开（公告）日：2019-09-03

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TLR7/8 antagonists.

  本发明涉及可用作 TLR7/8 拮抗剂的式 I 化合物及其药学上可接受的组合物。
• Synthesis of desosamines
  申请人：President and Fellows of Harvard College

  公开号：US10544182B2

  公开（公告）日：2020-01-28

  The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

  本发明提供脱糖胺和霉菌胺糖类似物和硝基糖及其制备方法。本发明还提供了式(A′)化合物与乙二醛环化得到式(B)硝基糖的方法。本发明提供了制备式(D′)化合物的方法，包括硝基醇环化得到硝基糖，硝基糖还原和烷基化得到脱糖胺、霉菌胺糖或其类似物。
• Bruton's tyrosine kinase inhibitors
  申请人：Sunesis Pharmaceuticals, Inc.

  公开号：US10577374B2

  公开（公告）日：2020-03-03

  The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.

  本发明提供了可用作 Btk 抑制剂的化合物、其组合物及其使用方法。