butyl phthalimidomethyl trithiocarbonate | 19194-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: butyl phthalimidomethyl trithiocarbonate
• 英文别名: Trithiokohlensaeure-butylester-(phthalimido-N-methyl)-ester；trithiocarbonic acid butyl ester phthalimidomethyl ester；Phthalimidomethyl butyl trithiocarbonate；2-(butylsulfanylcarbothioylsulfanylmethyl)isoindole-1,3-dione
• CAS: 19194-21-9
• 化学式: C₁₄H₁₅NO₂S₃
• 分子量: 325.477
• InChiKey: OUCYVVFRLVYRSW-UHFFFAOYSA-N

物化性质

• 熔点：
  88-93°C
• 沸点：
  501.3±29.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  butyl phthalimidomethyl trithiocarbonate 、 叔丁氧基 N-氨基甲酸丙烯 在 过氧化双月桂酰 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以26%的产率得到S-[(1-tert-butoxycarbonylamino-4-phthalimido)butan-2-yl] S'-butyl trithiocarbonate
  参考文献：
  名称：

  Efficient synthesis of 5-substituted thiazolidin-2-ones from xanthates and tert-butyl N-allylcarbamates

  摘要：

  A series of 5-substituted thiazolidin-2-ones with various functional groups was synthesized efficiently via a radical addition of xanthates and tert-butyl N-allylcarbamates and subsequent 88% HCO2H-catalyzed cyclization. The mechanism of the acid-catalyzed cyclization was proposed as well. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.10.031
• 作为产物：
  描述：

  二硫化碳 、 N-氯甲基邻苯二甲酰亚胺 、 丁硫醇 在 potassium hydroxide 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 反应 0.75h， 以88%的产率得到butyl phthalimidomethyl trithiocarbonate
  参考文献：
  名称：

  Efficient synthesis of 5-substituted thiazolidin-2-ones from xanthates and tert-butyl N-allylcarbamates

  摘要：

  A series of 5-substituted thiazolidin-2-ones with various functional groups was synthesized efficiently via a radical addition of xanthates and tert-butyl N-allylcarbamates and subsequent 88% HCO2H-catalyzed cyclization. The mechanism of the acid-catalyzed cyclization was proposed as well. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.10.031

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。
• PROCESS FOR PREPARING INERT RAFT POLYMERS
  申请人：Universiteit Gent

  公开号：EP3018151A1

  公开（公告）日：2016-05-11

  This invention provides a process for preparing an inert RAFT polymer, comprising polymerizing a RAFT-polymerizable ethylenically unsaturated monomer in the presence of a thiocarbonylthio compound until the monomer conversion reaches a value between 40% and 90%, and further comprising, when such value has been reached, adding a 5-fold to 100-fold molar excess, with respect to the thiocarbonylthio compound, of a reducing agent capable of performing aminolysis of the thiocarbonylthio end groups of the polymer. This invention further relates to an inert RAFT polymer prepared by such process.

  本发明提供了一种制备惰性 RAFT 聚合物的工艺，包括在硫代羰基硫代化合物存在下聚合可进行 RAFT 聚合的乙烯基不饱和单体，直至单体转化率达到 40% 至 90% 之间的值，还包括在达到该值时，加入相对于硫代羰基硫代化合物摩尔过量 5 倍至 100 倍的还原剂，该还原剂能够对聚合物的硫代羰基硫代端基进行氨解。本发明还涉及一种通过上述工艺制备的惰性 RAFT 聚合物。
• ACRYLIC COPOLYMER, PREPARATION METHOD THEREFOR, AND ACRYLIC COPOLYMER COMPOSITION COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：EP3750928A1

  公开（公告）日：2020-12-16

  The present invention relates to an acrylic copolymer, and more particularly, to an acrylic copolymer including: a main monomer-derived repeating unit; and a chain transfer agent-derived part, wherein the main monomer-derived repeating unit includes a (meth)acrylic acid alkyl ester monomer-derived repeating unit, a (meth)acrylic acid alkoxy alkyl ester monomer-derived repeating unit, and a crosslinking monomer-derived repeating unit, the chain transfer agent-derived part is derived from a chain transfer agent having a carbonothioylthio group, and the chain transfer agent-derived part is included in an amount of 0.03 parts by weight to 0.08 parts by weight with respect to 100 parts by weight of the main monomer-derived repeating unit, a method of preparing the same, and an acrylic copolymer composition including the same.

  本发明涉及一种丙烯酸共聚物，更具体地说，涉及一种丙烯酸共聚物，包括其中主单体衍生的重复单元包括(甲基)丙烯酸烷基酯单体衍生的重复单元、(甲基)丙烯酸烷氧基烷基酯单体衍生的重复单元和交联单体衍生的重复单元，链转移剂衍生的部分由具有硫代碳酰基的链转移剂衍生，链转移剂衍生的部分以 0.以 100 份主单体衍生重复单元的重量计，链转移剂衍生部分的含量为 0.03 至 0.08 份（按重量计）；制备方法；以及包括上述内容的丙烯酸共聚物组合物。
• Cross-linked impact modified polyphosphazenes
  申请人：INTERNATIONAL BUSINESS MACHINES CORPORATION

  公开号：US11059960B2

  公开（公告）日：2021-07-13

  A flame retardant composition and a method of making a flame retardant composition is provided. In an embodiment, the method includes reacting a phosphazene material with an acrylamide monomer material to form a functionalized phosphazene material; initiating a polymerization reaction on a reaction mixture comprising a functionalized phosphazene material and one or more monomers to form a first impact-modified phosphazene material; and reacting the first impact-modified phosphazene material with a poly(dichlorophosphazene) monomer material, and a reactant selected from the group consisting of R1OH, HNR2R3, or a combination thereof, to form a second impact-modified phosphazene material.

  本发明提供了一种阻燃组合物和一种阻燃组合物的制造方法。在一个实施方案中，该方法包括将磷化烯材料与丙烯酰胺单体材料反应，形成官能化磷化烯材料；在包含官能化磷化烯材料和一种或多种单体的反应混合物上引发聚合反应，形成第一抗冲改性磷化烯材料；将第一抗冲改性磷苯材料与聚（二氯磷苯）单体材料和选自 R1OH、HNR2R3 或其组合的反应物反应，形成第二抗冲改性磷苯材料。