2-[2-(羧甲基)环丙基]乙酸 | 54010-19-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[2-(羧甲基)环丙基]乙酸
• 英文名称: cis-3,4-methylenehexanedioic acid
• 英文别名: 1,2-Cyclopropanediacetic acid；2-[2-(carboxymethyl)cyclopropyl]acetic acid
• CAS: 54010-19-4
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: JSRDBEGXQDOKHA-UHFFFAOYSA-N

物化性质

• 沸点：
  393.5±15.0 °C(Predicted)
• 密度：
  1.344±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2917209090

文献信息

• SALTS OF PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1091958A1

  公开（公告）日：2001-04-18
• [EN] SALTS OF PAROXETINE<br/>[FR] SELS DE PAROXETINE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2000001692A1

  公开（公告）日：2000-01-13

  Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.
• [EN] ORALLY DELIVERED THERAPEUTICAL COMPOSITION AND USE THEREOF<br/>[FR] COMPOSITION THÉRAPEUTIQUE ADMINISTRÉE PAR VOIE ORALE ET SON UTILISATION
  申请人：SHEN HAIFA

  公开号：WO2021046497A2

  公开（公告）日：2021-03-11

  This disclosure is directed to a pharmaceutical composition comprising a bioactive agent (active pharmaceutical ingredient, API) and at least one long chain fatty acid (LCFA), wherein the long chain fatty acid can comprise a carbon chain having at least 10 carbon atoms and can comprise a free carboxylic acid group or a salt thereof. The LCFA-conjugated active pharmaceutical ingredient (API) can be resistant to acid degradation in digestive system and facilitate the delivery of the API across the small intestinal epithelial cell membrane via fatty acid transport protein 4 (FATP4, also known as SLC27A4). The pharmaceutical composition can be formulated in acid- resistant (enteric-release) dosage forms for oral administration in patients. This disclosure is further directed to a process for producing the LCFA-conjugated bioactive agent including protein, polypeptide, small molecule drugs, DNA, RNA, oligonucleotide, or a combination thereof.