4-(2-[6-(4-tolyl)phenyl]pyridyl)benzoic acid | 351333-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(2-[6-(4-tolyl)phenyl]pyridyl)benzoic acid
• 英文别名: 4-(6-p-tolyl-pyridin-2-yl)-benzoic acid；4-[6-(4-Methylphenyl)pyridin-2-yl]benzoic acid
• CAS: 351333-74-9
• 化学式: C₁₉H₁₅NO₂
• 分子量: 289.334
• InChiKey: PVPGKUKVTYWSHF-UHFFFAOYSA-N

物化性质

• 沸点：
  483.1±33.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-[6-(4-tolyl)phenyl]pyridyl)benzoic acid 在 N-溴代丁二酰亚胺(NBS) 、 硫酸 、 sodium ethanolate 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 乙醇 为溶剂， 反应 3.17h， 生成 4-(2-[6-(4-[2-(dimethylamino)ethyl]thiomethyl)-phenyl]pyridyl)benzoate
  参考文献：
  名称：

  Mehta, Lina K.; Parrick, John; Sadiq, Samina, Journal of Chemical Research, Miniprint, 2000, # 11, p. 1221 - 1236

  摘要：

  DOI：
• 作为产物：
  描述：

  4-乙酰基苯甲酸 在 乙酸铵 、 盐酸 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 6.0h， 生成 4-(2-[6-(4-tolyl)phenyl]pyridyl)benzoic acid
  参考文献：
  名称：

  Mehta, Lina K.; Parrick, John; Sadiq, Samina, Journal of Chemical Research, Miniprint, 2000, # 11, p. 1221 - 1236

  摘要：

  DOI：

文献信息

• Compounds for Nonsense Suppression, and Methods for Their Use
  申请人：Almstead Neil

  公开号：US20080119473A1

  公开（公告）日：2008-05-22

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

  本发明涉及使用本发明的化合物或组合物治疗或预防与mRNA中的无义突变相关的疾病的方法、化合物和组合物。更具体地，本发明涉及抑制与mRNA中的无义突变相关的早期翻译终止的方法、化合物和组合物。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH
  申请人：PTC THERAPEUTICS, INC

  公开号：US20160199357A1

  公开（公告）日：2016-07-14

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无意义突变的核酸序列编码的功能蛋白质。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能蛋白质的方法，并使用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
  申请人：PTC Therapeutics, Inc.

  公开号：EP2387995A1

  公开（公告）日：2011-11-23

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由包含无义突变的核酸序列编码的功能性蛋白质。本发明还涉及生产由包含无义突变的核酸序列编码的功能性蛋白质的方法，以及将这种蛋白质用于预防、控制和/或治疗与基因中的无义突变有关的疾病的方法。
• COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
  申请人：PTC Therapeutics, Inc.

  公开号：EP1799212A2

  公开（公告）日：2007-06-27