6-Diphenylphosphinoyldecane-2,5-dione | 135440-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-Diphenylphosphinoyldecane-2,5-dione
• 英文别名: 6-diphenylphosphoryldecane-2,5-dione
• CAS: 135440-62-9
• 化学式: C₂₂H₂₇O₃P
• 分子量: 370.428
• InChiKey: PBFWYJCMPMSMPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-Diphenylphosphinoyldecane-2,5-dione 在 Amberlyst 15 resin 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以96%的产率得到2-(1-diphenylphosphinoylpentyl)-5-methylfuran
  参考文献：
  名称：

  The synthesis of (Z)-penta-2,4-dien-1-ol and substituted (E)-pentadienols by the stereochemically controlled Horner–Wittig reaction

  摘要：

  Acylation of Ph2P(O)Me with a lactone gives a Horner-Wittig intermediate with a Z-double bond protected as a Diels-Alder adduct with furan and hence (Z)-penta-2,4-dien-1-ol. Substituted (E)-penta-2,4-dien-1-ols are available by a more general route involving addition of enals to phosphine oxides, a regiochemically controlled allylic alcohol transposition, and a Horner-Wittig reaction. The geometry of only one double bond can be controlled.

  DOI：

  10.1039/p19910001485
• 作为产物：
  描述：

  6-Diphenylphosphinoyloctan-5-oxodecan-2-ol 在 jones reagent 作用下， 以 丙酮 为溶剂， 反应 0.75h， 以93%的产率得到6-Diphenylphosphinoyldecane-2,5-dione
  参考文献：
  名称：

  The synthesis of (Z)-penta-2,4-dien-1-ol and substituted (E)-pentadienols by the stereochemically controlled Horner–Wittig reaction

  摘要：

  Acylation of Ph2P(O)Me with a lactone gives a Horner-Wittig intermediate with a Z-double bond protected as a Diels-Alder adduct with furan and hence (Z)-penta-2,4-dien-1-ol. Substituted (E)-penta-2,4-dien-1-ols are available by a more general route involving addition of enals to phosphine oxides, a regiochemically controlled allylic alcohol transposition, and a Horner-Wittig reaction. The geometry of only one double bond can be controlled.

  DOI：

  10.1039/p19910001485