5-(3-carboxy-4-methoxybenzyl)-2-methoxybenzoic acid | 227595-84-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(3-carboxy-4-methoxybenzyl)-2-methoxybenzoic acid
• 英文别名: 6,6'-dimethoxy-3,3'-methanediyl-di-benzoic acid；6,6'-Dimethoxy-3,3'-methandiyl-di-benzoesaeure；5-[(3-Carboxy-4-methoxyphenyl)methyl]-2-methoxybenzoic acid
• CAS: 227595-84-8
• 化学式: C₁₇H₁₆O₆
• 分子量: 316.31
• InChiKey: MLUAPHKLURDONQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(3-carboxy-4-methoxybenzyl)-2-methoxybenzoic acid 在 吡啶 、 硫酸 、 一水合肼 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 31.0h， 生成 6-(2-methoxy-5-4-methoxy-3-[3-(4-nitrophenyl)[1,2,4]triazolo[3,4-b][1,3,4]oxadiazol-6-yl]benzylphenyl)-3-(4-nitrophenyl)[1,2,4]triazolo[3,4-b][1,3,4]oxadiazole
  参考文献：
  名称：

  新型双[1,2,4]三唑[3,4-b] [1,3,4]恶二唑的合成及生物评价

  摘要：

  一系列新颖的6-2-甲氧基-5- [4-甲氧基3-（3-芳基[1,2,4]三唑[3,4- b ] [1,3,4]恶二唑-6-基）苄基]苯基-3-芳基[1,2,4]三唑[3,4- b ] [1,3,4]恶二唑7a，7b，7c，7d，7e，7f，7g，7h，7i，7j已通过IR，1 H NMR，13 C NMR，MS和元素分析合成并表征。化合物7a，7b，7c，7d，7e，1408米，7克，7H，7I，7J还筛选了他们对革兰氏阳性菌的抗菌活性即。枯草芽孢杆菌（MTCC 441），球形芽孢杆菌（MTCC 11）和金黄色葡萄球菌（MTCC 96），和革兰氏阴性菌即。铜绿假单胞菌（MTCC 741），铜绿假单胞菌（MTCC 39）和紫罗兰色杆菌（MTCC 2656）。抗菌筛查表明，存在2-吡唑基的2,4-二氟苯基（7e）或4-硝基苯基（7f）（三唑部分上的7i）或2-呋喃基（7j）在测试浓度下显示出

  DOI：

  10.1002/jhet.1528
• 作为产物：
  描述：

  bis(3-formyl-p-anisyl)methane 在 ammonium hydroxide 、 sodium hydroxide 、 silver nitrate 作用下， 生成 5-(3-carboxy-4-methoxybenzyl)-2-methoxybenzoic acid
  参考文献：
  名称：

  Ishiwata; Takada, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 1254

  摘要：

  DOI：

文献信息

• Process for producing aromatic polyamides
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0328342A2

  公开（公告）日：1989-08-16

  Aromatic polyamides are produced by subjecting an aromatic diisocyanate and an aromatic dicarboxylic acid to polycondensation in the presence of an alkali metal compound and/or an alkaline earth metal compound as a catalyst in an aprotonic polar solvent. The aromatic polyamide can be rendered suitable for use in the production of high-tenacity fibers by charging in advance the solvent, aromatic dicarboxylic acid and catalyst in a mixing system, reducing the water content in the mixing system to 50 ppm or below and then introducing the aromatic diisocyanate to conduct the polycondensation reaction.

  芳香族聚酰胺的生产方法是：在有碱金属化合物和/或碱土金属化合物作为催化剂的情况下，在质子极性溶剂中将芳香族二异氰酸酯和芳香族二羧酸进行缩聚。 在混合系统中预先加入溶剂、芳香族二羧酸和催化剂，将混合系统中的水含量降至 50ppm 或以下，然后引入芳香族二异氰酸酯进行缩聚反应，可使芳香族聚酰胺适用于生产高韧性纤维。
• TREATING AGENT FOR LIQUID CRYSTAL ALIGNMENT LAYER AND LIQUID CRYSTAL DEVICE USING THE SAME, AND METHOD FOR ALIGNMENT OF LIQUID CRYSTAL
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP1111442A1

  公开（公告）日：2001-06-27

  Object Liquid crystal-alignment agent where uniform liquid alignment of liquid crystals is effectively manifested by the irradiation with light over the liquid crystal alignment film without rubbing treatment of the liquid crystal alignment film thereof, and further manifests liquid crystal alignment with high stability and high light resistance, liquid crystals device with the use of said alignment agent and the method of the liquid crystal alignment by the use of said liquid crystal alignment agent. Constitution Liquid crystal alignment agent where polymer compound having bonds shown in the general formula (1) - (7) below wherein R1, R2 and R3 are independently of each other hydrogen, alkyl, substituted alkyl, aryl or propargyl; in the polymer compound thereof with number-average molecular weight of 1,000 - 300,000, and said bond makes the direct bond with either divalent or trivalent aromatic group at the both ends of said bond or with divalent or trivalent aromatic group making the direct bond at one end while at the other forming the direct bond with divalent or trivalent alicyclic hydrocarbon group, liquid crystal device by the use of said liquid crystal alignment agent and the method of the liquid crystal alignment by the use of said liquid crystal alignment agent.

  目标 无需对液晶对位膜进行摩擦处理，通过对液晶对位膜进行光照射，即可有效实现液晶的均匀液态对位，并进一步实现高稳定性和高耐光性液晶对位的液晶对位剂、使用所述对位剂的液晶装置以及使用所述液晶对位剂的液晶对位方法。 构成 液晶配向剂，其中的聚合物化合物具有以下通式（1）-（7）所示的键 其中 R1、R2 和 R3 相互独立地为氢、烷基、取代烷基、芳基或丙基；在其平均分子量为 1,000 - 300,000 的聚合物化合物中，所述键在所述键的两端与二价或三价芳香族基团直接键合，或在一端与二价或三价芳香族基团直接键合，而在另一端与二价或三价脂环烃基团直接键合，通过使用所述液晶配向剂的液晶装置和通过使用所述液晶配向剂的液晶配向方法。
• Reddy, Ch. Sanjeeva; Raghu; Nagaraj, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 2, p. 315 - 318
  作者：Reddy, Ch. Sanjeeva、Raghu、Nagaraj

  DOI：——

  日期：——
• Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes
  作者：Avula Srinivas

  DOI：10.17344/acsi.2015.2124

  日期：2016.3.15

  A series of novel bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes (5a-e and 6a-e) has been synthesized and characterized by IR, H-1 and C-13 NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacterium violaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d, 5e, 6b, 6c and 6e exhibited potent activity against the tested bacteria and fungi, and emerged as potential molecules for further development.
• Kumar, Gaddam Rajesh; Shankar, Kurre; Reddy, Cherkupally Sanjeeva, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2018, p. 700 - 714
  作者：Kumar, Gaddam Rajesh、Shankar, Kurre、Reddy, Cherkupally Sanjeeva

  DOI：——

  日期：——