Methyl 2-[hydroxy-[3-(4-methylphenyl)-1,2-oxazol-5-yl]methyl]prop-2-enoate | 337355-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-[hydroxy-[3-(4-methylphenyl)-1,2-oxazol-5-yl]methyl]prop-2-enoate
• CAS: 337355-84-7
• 化学式: C₁₅H₁₅NO₄
• 分子量: 273.288
• InChiKey: SYFOXRGVSFHAMV-UHFFFAOYSA-N

物化性质

• 沸点：
  476.5±45.0 °C(Predicted)
• 密度：
  1.209±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 2-[hydroxy-[3-(4-methylphenyl)-1,2-oxazol-5-yl]methyl]prop-2-enoate 在 吡啶 、 氢氧化钾 、 sodium tetrahydroborate 、 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 、 1-羟基苯并三唑 、 达卡巴嗪 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.25h， 生成
  参考文献：
  名称：

  Isoxazole-based derivatives from Baylis–Hillman chemistry: assessment of preliminary hypolipidemic activity

  摘要：

  The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00105-6
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 3-(p-tolyl)isoxazole-5-carbaldehyde 在 三乙烯二胺 作用下， 反应 0.5h， 以81%的产率得到Methyl 2-[hydroxy-[3-(4-methylphenyl)-1,2-oxazol-5-yl]methyl]prop-2-enoate
  参考文献：
  名称：

  5-Isoxazolecarboxaldehyde: A Novel Substrate for Fast Baylis-Hillman Reaction

  摘要：

  3-Aryl-5-isoxazolecarboxaldehyde 与多种活化烯发生快速 Baylis-Hillman 反应，生成相应的加合物，收率极高。此处报告的一些 Baylis-Hillman 加合物随后经过改性，得到了异噁唑取代的吡唑啉-3-酮和δ-丁内酯。

  DOI：

  10.1055/s-2001-10815

文献信息

• Unusual retention of isoxazole ring under the influence of 3-(substituted nitrophenyl)-2-isoxazoline during catalytic hydrogenation of isoxazoline-substituted isoxazole systems
  作者：Vijay Singh、Samiran Hutait、Gaya P. Yadav、Prakas R. Maulik、Sanjay Batra

  DOI：10.1002/jhet.87

  日期：2009.7

  The cleavage of the isoxazole ring during the Raney-Ni-promoted catalytic hydrogenation is prevented under the influence of 3-(substituted nitrophenyl)-2-isoxazoline in isoxazoline-substituted isoxazole systems produced via 1,3-dipolar cycloaddition either on the Baylis–Hillman derivatives or Grignard products. Unexpectedly, the hydrogenations in these diastereomeric compounds were observed to exclusively

  在阮内镍促进的催化加氢过程中，在3-（取代的硝基苯基）-2-异恶唑啉的影响下，异恶唑环的裂解被阻止，该异恶唑啉取代的异恶唑系统是通过在Baylis上的1，3-偶极环加成生成的异恶唑啉取代的异恶唑系统希尔曼衍生品或格利雅产品。出乎意料的是，观察到这些非对映体化合物中的氢化仅产生产物，其中甲氧基羰基和羟基或乙酰基彼此同义地存在。J.杂环化​​学，（2009）。
• Studies on the catalytic hydrogenation of Baylis–Hillman derivatives of substituted isoxazolecarbaldehydes. Unusual retention of isoxazole ring during Pd–C-promoted hydrogenation of Baylis–Hillman adducts
  作者：R. Saxena、V. Singh、S. Batra

  DOI：10.1016/j.tet.2004.08.068

  日期：2004.11

  Results of the catalytic hydrogenation of Baylis–Hillman adducts obtained from substituted 3-, 4- and 5-isoxazolecarbox-aldehydes and their corresponding acetates in the presence of Raney-Ni and Pd–C are presented. The hydrogenation of Baylis–Hillman adducts of substituted 5-isoxazolecarbaldehydes and 3-isoxazolecarbaldehydes in the presence of Raney-Ni furnishes diastereoselectively syn enaminones

  给出了在阮内镍和钯-碳存在下从取代的3-，4-和5-异恶唑羧醛及其相应的乙酸盐获得的Baylis-Hillman加合物催化加氢的结果。取代的5- isoxazolecarbaldehydes和在阮内镍的存在下3-isoxazolecarbaldehydes的的Baylis-希尔曼加合物的氢化的配料非对映选择性顺式烯胺酮过抗并在硼酸的存在下有利于非对映选择性的添加剂进一步增强顺式异构体，观察到。Pd–C促进的这些底物的氢化也具有非对映选择性，有利于合成异构体，但不发生异恶唑环的氢解。在该氢化中硼酸作为添加剂的存在对非对映选择性没有显着影响。Raney-Ni介导的取代的4-异恶唑甲醛的Baylis-Hillman加合物的加氢反应产生吡啶酮衍生物，而Pd-C促进的同一底物的加氢反应是非对映选择性的，从而提供了所得产物的反异构体。衍生自3-和5-异恶唑甲醛的Baylis-Hillman加合物的烯胺酮可作为α'-羟基-1
• NaBH₄-mediated FacileReduction of Esters of Baylis-Hillman Adducts: An EfficientApproach to Substituted Propane-1,3-Diols
  作者：Sanjay Batra、Arundhati Patra、Amiya P. Bhaduri

  DOI：10.1055/s-2003-40992

  日期：——

  Reduction of the ester group in the Baylis-Hillman adductsby NaBH4 reduction is facilitated by the secondary hydroxyl grouppresent at their β-position. This method is efficient forthe preparation of substituted propane-1,3-diols.

  通过 NaBH4 还原法还原 Baylis-Hillman 加合物中的酯基时，其 δ 位上存在的仲羟基会起到促进作用。这种方法可以有效地制备取代的丙烷-1,3-二醇。
• Baylis–Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
  作者：S. Batra、A.K. Roy、A. Patra、A.P. Bhaduri、W.R. Surin、S.A.V. Raghavan、P. Sharma、K. Kapoor、M. Dikshit

  DOI：10.1016/j.bmc.2004.02.023

  日期：2004.5

  The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted -5-isoxazolecarb-aldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented. (C) 2004 Elsevier Ltd. All rights reserved.
• The Baylis–Hillman chemistry in aqueous media: elucidation of mechanism for synthesis of ether side-product leads to an efficient approach to C–O bond formation
  作者：A Patra、A.K Roy、B.S Joshi、R Roy、S Batra、A.P Bhaduri

  DOI：10.1016/s0040-4020(02)01561-2

  日期：2003.1

  The formation of an ether from the Baylis-Hillman (BH) adduct during the BH reaction of 5-isoxazolecarboxaldehydes is a common phenomenon if the reaction is allowed to proceed for longer periods. The amount of formation of such ethers depends on the acrylates used and is most significant for tert-butyl acrylates. A study of the plausible mechanism for the formation of these side-products led to reactions of acetates of BH adducts with phenol in aqueous media to yield the corresponding 3-phenoxy alk-2-enoates in good yields. The successful translation of solution phase methodology to solid phase for application towards combinatorial chemistry is discussed. (C) 2003 Elsevier Science Ltd. All rights reserved.