1,2-Epoxy-3-(2-methylthiophenoxy)-propan | 13379-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2-Epoxy-3-(2-methylthiophenoxy)-propan
• 英文别名: 2-{[2-(Methylsulfanyl)phenoxy]methyl}oxirane；2-[(2-methylsulfanylphenoxy)methyl]oxirane
• CAS: 13379-85-6
• 化学式: C₁₀H₁₂O₂S
• 分子量: 196.27
• InChiKey: BVPTWWOAYRPTPY-UHFFFAOYSA-N

物化性质

• 沸点：
  106-108 °C(Press: 0.2 Torr)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(吲哚-3-基)-2-甲基-2-丙胺 、 1,2-Epoxy-3-(2-methylthiophenoxy)-propan 反应 0.5h， 生成 1-[[2-(3-indolyl)-1,1-dimethylethyl]amino]-3-[2-(methylthio)phenoxy]-2-propanol
  参考文献：
  名称：

  Antihypertensive indole derivatives of phenoxypropanolamines with .beta.-adrenergic receptor antagonist and vasodilating activity

  摘要：

  A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl [i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), beta-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with beta adrenergic receptor antagonist and vasodilating action. The structure--activity relationships in these tests are discussed.

  DOI：

  10.1021/jm00177a015
• 作为产物：
  描述：

  2-羟基茴香硫醚 在 哌啶 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 0.67h， 生成 1,2-Epoxy-3-(2-methylthiophenoxy)-propan
  参考文献：
  名称：

  Antihypertensive indole derivatives of phenoxypropanolamines with .beta.-adrenergic receptor antagonist and vasodilating activity

  摘要：

  A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl [i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), beta-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with beta adrenergic receptor antagonist and vasodilating action. The structure--activity relationships in these tests are discussed.

  DOI：

  10.1021/jm00177a015

文献信息

• [EN] 5-HT1A AND 5-HT1D alpha ANTAGONISTS<br/>[FR] ANTAGONISTES DE 5-HT1A ET 5-HT1D alpha
  申请人：ELI LILLY AND COMPANY

  公开号：WO1998053823A1

  公开（公告）日：1998-12-03

  (EN) A class of novel substituted-aryloxy-2-ol-3-(4-spiro-(alkanedioxy)isobenzofuranyl- and phthaloyl-piperidine) derivatives is disclosed useful as 5-HT1A and 5-HT1D$g(a) antagonists.(FR) Cette invention se rapporte à une classe de nouveaux dérivés aryloxy-2-ol-3-(4-spiro-(alcanedioxy)isobenzofuranyl- et phtaloyl-pipéridine) substitués qui s'avèrent utiles en tant qu'antagonistes de 5-HT1A ET 5-HT1D$g(a).

  一种新型取代芳氧基-2-醇-3-(4-螺环(烷二氧基)异吲唑并呋喃和对苯二甲酰哌啶)衍生物被披露，可用作5-HT1A和5-HT1D\$g(a)拮抗剂。
• KREIGHBAUM W. E.; MATIER W. L.; DENNIS R. D.; MINIELLI J. L.; DEITCHMAN D+, J. MED. CHEM., 1980, 23, NO 3, 285-289
  作者：KREIGHBAUM W. E.、 MATIER W. L.、 DENNIS R. D.、 MINIELLI J. L.、 DEITCHMAN D+

  DOI：——

  日期：——