2-[4-(氯甲基)苯基]乙酸甲酯 | 72770-09-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[4-(氯甲基)苯基]乙酸甲酯
• 中文别名: 4-氯甲基苯乙酸甲酯
• 英文名称: 4-(chloromethyl)-phenylacetic methylester
• 英文别名: methyl acetate；methyl 4-chloromethylphenylacetate；4-(chloromethyl) phenylacetic methylester；methyl 2-(4-(chloromethyl)phenyl)acetate；Methyl 2-[4-(chloromethyl)phenyl]acetate
• CAS: 72770-09-3
• 化学式: C₁₀H₁₁ClO₂
• mdl: MFCD09998926
• 分子量: 198.649
• InChiKey: NLDHYHVAHJGITR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[4-(氯甲基)苯基]乙酸甲酯 在 乌洛托品 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 对甲酰基苯基乙酸甲酯
  参考文献：
  名称：

  Formation of heptafulvene in reactions of [(methoxycarbonyl)methyl]phenylcarbene in the gas phases

  摘要：

  Flash vacuum pyrolysis of [[(methoxycarbonyl)methyl]phenyl]diazomethanes produced 1-(methoxycarbonyl)benzocyclobutene, as a result of intramolecular C-H insertion in the ortho isomer of [[(methoxycarbonyl)methyl]phenyl]carbene generated by carbene-carbene rearrangement, and 8-(methoxycarbonyl) heptafulvene, presumably formed by intramolecular H migration in the seven-membered ring intermediates involved in the rearrangement.

  DOI：

  10.1021/jo00068a008
• 作为产物：
  描述：

  苯乙酸 在 盐酸 、 溶剂黄146 、 paraformaldehyde 作用下， 生成 2-[4-(氯甲基)苯基]乙酸甲酯
  参考文献：
  名称：

  A process for the production of benzene derivatives

  摘要：

  公开号：

  EP0889020B1

文献信息

• INDAZOLE DERIVATIVES AS ADENOSINE MONOPHOSPHATE DEAMINASE (AMPD) INHIBITORS FOR USE IN DIABETES AND RELATED DISEASES OF METABOLIC SYNDROME
  申请人：Ochs Raymond S.

  公开号：US20120130078A1

  公开（公告）日：2012-05-24

  Herein, we describe a method for treatment of diabetes and other disorders classified as Metabolic Syndrome. The invention provides novel AMP Deaminase (AMPD) inhibitors comprising novel indazole and benzotriazole derivatives including a phosphorous containing derivative, a carboxylic acid, or an amino acid ester prodrug. The invention also provides support for a novel mechanism of action for the existing drug metformin: direct inhibition of the enzyme AMPD. The inhibition of AMPD in turn activates AMP Kinase, known to be linked to the action of metformin. The invention also makes novel use of a double inhibitor assay allowing identification of selective AMPD inhibitors over ADA inhibitors. The new inhibitors, structurally distinct from metformin, offer selectivity that may obviate side effects known for metformin itself, providing new benefits for diabetes and Metabolic Syndrome.

  在这里，我们描述了一种治疗糖尿病和其他归类为代谢综合征的疾病的方法。该发明提供了一种新型的AMP脱氨酶（AMPD）抑制剂，包括新型的吲唑和苯并三唑衍生物，其中包括含磷衍生物、羧酸或氨基酸酯前药。该发明还支持现有药物二甲双胍的一种新颖作用机制：直接抑制AMPD酶。抑制AMPD反过来激活AMP激酶，已知与二甲双胍的作用有关。该发明还首次使用了一种双重抑制剂分析，允许识别对ADA抑制剂具有选择性的AMPD抑制剂。这些新抑制剂在结构上与二甲双胍不同，提供的选择性可能消除二甲双胍本身已知的副作用，为糖尿病和代谢综合征带来新的益处。
• Process for the production of benzene derivatives
  申请人：Kolon Industries, Inc.

  公开号：US06013832A1

  公开（公告）日：2000-01-11

  The present invention relates to a process for the production of benzene derivatives represented by formula (I), which are useful as intermediates for agricultural chemicals, fine chemical products or pharmaceuticals such as anti inflammatory analgesics. The process includes reacting a compound of chemical formula (II) with a hydroformylating agent and a halogenating agent. ##STR1##

  这项发明涉及一种生产苯衍生物的方法，该苯衍生物由式(I)表示，可用作农药、精细化工产品或药物（如抗炎镇痛药）的中间体。该方法包括将化学式(II)的化合物与羰基化剂和卤化剂反应。
• NOVEL BIS(FORMYLPHENYL)ALKANE AND NOVEL POLYNUCLEAR PHENOL DERIVED FROM THE SAME
  申请人：Yoshitomo Akira

  公开号：US20100016633A1

  公开（公告）日：2010-01-21

  Manufacture a novel bis(formylphenyl)alkane according to General Formula (1), as well as a novel polynuclear phenol derived therefrom, by causing a bis(hydroxymethyl-hydroxyphenyl)alkane to react with hexamethylene tetramine in the presence of an acid and hydrolyzing the reaction product, and then using the obtained bis(hydroxy-formylphenyl)alkane as a direct material and causing this material to react with halogenated alkoxycarbonyl hydrocarbon in the presence of a base.

  根据通用公式（1），制造一种新型双(甲醛苯基)烷，并由此制备一种新型多核酚，方法是使双(羟甲基-羟基苯基)烷在酸的存在下与六亚甲基四胺反应并水解反应产物，然后使用得到的双(羟基-甲醛苯基)烷作为直接原料，使其在碱的存在下与卤代烷氧羰基碳氢化合物反应。
• Cyclopropylacetic Acid Derivatives and Use Thereof
  申请人：Becker Eva-Maria

  公开号：US20090286882A1

  公开（公告）日：2009-11-19

  The present application relates to novel cyclopropylacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的环丙基乙酸衍生物，涉及其制备过程，涉及它们用于治疗和/或预防疾病的用途，以及它们用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
• [EN] SUBSTITUTED ARYL PYRIMIDINONES<br/>[FR] ARYL PYRIMIDINONES SUBSTITUÉS
  申请人：NEUROGEN CORP

  公开号：WO2009100403A1

  公开（公告）日：2009-08-13

  Substituted aryl pyrimidinones are provided, of the Formula (I) wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了替代芳基嘧啶酮，其化学式为（I），其中变量如本文所述。这些化合物是配体，可用于调节体内或体外特定受体的活性，并且在治疗与人类、家养伴侣动物和家畜动物中的病理性受体激活相关的疾病方面特别有用。提供了用于治疗这些疾病的药物组合物和方法，以及用于受体定位研究的配体的使用方法。