3,6,9-trioxaundecane-1,11-dioic acid anhydride | 945606-69-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,6,9-trioxaundecane-1,11-dioic acid anhydride
• 英文别名: 1,4,7,10-Tetraoxacyclododecane-2,12-dione
• CAS: 945606-69-9
• 化学式: C₈H₁₂O₆
• 分子量: 204.18
• InChiKey: JSIQNKBDBKMLMO-UHFFFAOYSA-N

物化性质

• 沸点：
  360.9±27.0 °C(Predicted)
• 密度：
  1.200±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,6,9-trioxaundecane-1,11-dioic acid anhydride 、 7-chloro-2,3,4,5-tetrahydro-1H-azepine-1-carbaldehyde 以 甲苯 为溶剂， 反应 6.0h， 以78%的产率得到
  参考文献：
  名称：

  使用环状α-氯代烯甲酰胺和环状酸酐一键式访问异喹诺酮和（杂）叠氮酮构架†

  摘要：

  功能化的叠氮酮和异喹啉酮是生物活性分子中常见的基序。在这里，我们描述了[6，n ]和[7，n ] -1-氮杂双环不饱和内酰胺的直接和模块化方法，其中大多数带有至少一个内环杂原子。涉及环状α-氯代烯甲酰胺和环状酸酐之间的选择性位六价反应。Castagnoli-Cushman反应中酸酐组分的范围已扩展到5元，6元和7元环。

  DOI：

  10.1039/c8nj06539j
• 作为产物：
  描述：

  3,6,9-三噁十一烷二酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 3,6,9-trioxaundecane-1,11-dioic acid anhydride
  参考文献：
  名称：

  Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

  摘要：

  Seven PNA-encoded combinatorial libraries targeting proteases and phosphatases with covalent reversible and irreversible mechanism-based inhibitors were prepared. The libraries were synthesized using modified PNA monomers, which dramatically increase the water solubility of the libraries in biologically relevant buffers. The libraries were shown to selectively inhibit targeted enzymes. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.033

文献信息

• Fibrin-Binding Peptides and Conjugates Thereof
  申请人：Bussat Philippe

  公开号：US20100158814A1

  公开（公告）日：2010-06-24

  Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

  本发明提供了与先前已知的纤维蛋白结合肽相比，具有高结合亲和力和优异物理特性的纤维蛋白结合肽。这些纤维蛋白结合肽可以与可检测标记或治疗剂结合，并用于检测和促进与纤维蛋白存在相关的病理状态的治疗，例如血栓、血管生成和肿瘤性疾病。这些肽可以用于成像过程，例如MRI、超声和核医学成像（例如PET、放射性核素成像等）。这些肽也可以用于治疗。本发明还提供了制备和使用这些肽及其结合物的过程和方法。
• Oxidising compositions
  申请人：WARWICK INTERNATIONAL GROUP LIMITED(Company No. 2754514)

  公开号：EP0534772A2

  公开（公告）日：1993-03-31

  A polyacid polyanhydride is used as a bleach activator especially for improving low temperature bleaching performance of peroxygen bleaches such as hydrogen peroxide or sodium perborate, in laundry and other detergent formulations. The polyanhydrides are preferably made from polybasic, usually dibasic, carboxylic acids, which may be aliphatic and/or aromatic in nature. The polyanhydride may be a homopolymer or a copolymer and has at least 2 monomer units on average per chain. The polyanhydride is preferably made by reacting the free dibasic acids with excess acetic anhydride and refluxing until the desired molecular weight is achieved followed by removal of acetic acid formed and excess acetic anhydride. Examples of polyanhydrides are polymers of sebacic, adipic, azelaic, succinic, fumaric, iso- and per-phthalic and citric acids. The polyanhydrides are solids which are easy to handle, relatively storage stable and give bleach activation.

  多酸酐可用作漂白剂活化剂，特别是用于改善过氧化氢或过硼酸钠等过氧漂白剂在洗衣粉和其他洗涤剂配方中的低温漂白性能。多酸酐最好由多基（通常为二基）羧酸制成，其性质可以是脂肪族和/或芳香族。聚酐可以是均聚物或共聚物，每条链平均至少有 2 个单体单元。聚酸酐最好通过游离二元酸与过量乙酸酐反应并回流，直到达到所需的分子量，然后除去形成的乙酸和过量的乙酸酐制成。多酸酐的例子包括癸二酸、己二酸、壬二酸、琥珀酸、富马酸、间苯二甲酸和柠檬酸的聚合物。多酸酐是固体，易于处理，储存相对稳定，并具有漂白活性。
• WO2008/75192
  申请人：——

  公开号：——

  公开（公告）日：——
• FIBRIN-BINDING PEPTIDES AND CONJUGATES THEREOF
  申请人：BRACCO IMAGING S.p.A.

  公开号：EP2111237A2

  公开（公告）日：2009-10-28
• US8278274B2
  申请人：——

  公开号：US8278274B2

  公开（公告）日：2012-10-02