2-amino-6-hydroxy-4-(4-hydroxyphenyl)pyrimidine-5-carbonitrile | 1160740-50-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-amino-6-hydroxy-4-(4-hydroxyphenyl)pyrimidine-5-carbonitrile
• 英文别名: 2-amino-4-hydroxy-6-(4-hydroxyphenyl)pyrimidine-5-carbonitrile；2-amino-4-(4-hydroxyphenyl)-6-oxo-1H-pyrimidine-5-carbonitrile
• CAS: 1160740-50-0
• 化学式: C₁₁H₈N₄O₂
• 分子量: 228.21
• InChiKey: UDYLYLYSBYLZEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氯甲基苯并咪唑 、 2-amino-6-hydroxy-4-(4-hydroxyphenyl)pyrimidine-5-carbonitrile 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以78%的产率得到2-((1H-benzo[d]imidazol-2-yl)methylamino)-1,6-dihydro-4-(4-hydroxyphenyl)-6-oxopyrimidine-5-carbonitrile
  参考文献：
  名称：

  新型苯并咪唑衍生物作为丙型肝炎病毒RNA复制抑制剂的合成，分子建模和生物学评估。

  摘要：

  在这项研究中，进行了一系列新的苯并咪唑衍生物的合成和对接研究，这些衍生物通过亚甲基硫键或其生物等位亚甲基氨基桥与取代的嘧啶连接。评价所有合成的化合物的丙型肝炎病毒（HCV）RNA复制抑制活性。发现化合物4d，4f和4h比VX-950更有效（IC50 / 90为4d = 0.123 / 0.321、4f = 0.145 / 0.345、4h = 0.129 / 0.432，VX-950 = 0.20 / 0.45 µM ）和6d（IC50 / 90 = 0.116 / 0.452 µM）所显示的活性与标准品非常相似。化合物4d，4f，4h和6d是有效的HCV RNA复制抑制剂，是进一步研究的良好候选药物。

  DOI：

  10.1248/cpb.c13-01009
• 作为产物：
  描述：

  碳酸胍 、 对羟基苯甲醛 、 氰乙酸乙酯 在 NH₂-SBA-15 mesoporous silica 作用下， 以 乙醇 为溶剂， 反应 3.17h， 以67%的产率得到2-amino-6-hydroxy-4-(4-hydroxyphenyl)pyrimidine-5-carbonitrile
  参考文献：
  名称：

  Amino-functionalized SBA-15 catalyzed one-step synthesis of 2-amino-5-cyano-4-hydroxy-6-aryl pyrimidines

  摘要：

  现已开发出一种简单高效的方法，可一步合成 2-氨基-5-氰基-4-羟基-6-芳基嘧啶。该方法基于脂肪族、芳香族或杂环醛、氰乙酸乙酯和碳酸胍在氨基官能化 SBA-15 催化剂存在下于乙醇中的三组分缩合。在这一化学过程中，观察到了嘧啶衍生物的同分异构体相互转化。这种高效的技术具有利用异相催化剂高产率生成 2-氨基嘧啶衍生物、反应时间短、产品分离过程简单等优点。

  DOI：

  10.1007/s13738-012-0189-x

文献信息

• Synthesis, Molecular Modeling, and Biological Evaluation of Novel Benzimidazole Derivatives as Inhibitors of Hepatitis C Virus RNA Replication
  作者：Hoda Ibrahim El Diwani、Heba Tawfik Abdel-Mohsen、Ismail Salama、Fatma Abdel-Fattah Ragab、Mostafa Mahmoud Ramla、Shadia Ahmed Galal、Mohamed Mostafa Abdalla、Abeer Abdel-Wahab、Maha Adel El Demellawy

  DOI：10.1248/cpb.c13-01009

  日期：——

  In this study, synthesis and docking studies of a series of new benzimidazole derivatives linked to substituted pyrimidines either through the methylenethio linkage or its bioisosteric methylene amino bridge were carried out. All the synthesized compounds were evaluated for their hepatitis C virus (HCV) RNA replication-inhibitory activity. Compounds 4d, 4f, and 4h were found to be more potent than

  在这项研究中，进行了一系列新的苯并咪唑衍生物的合成和对接研究，这些衍生物通过亚甲基硫键或其生物等位亚甲基氨基桥与取代的嘧啶连接。评价所有合成的化合物的丙型肝炎病毒（HCV）RNA复制抑制活性。发现化合物4d，4f和4h比VX-950更有效（IC50 / 90为4d = 0.123 / 0.321、4f = 0.145 / 0.345、4h = 0.129 / 0.432，VX-950 = 0.20 / 0.45 µM ）和6d（IC50 / 90 = 0.116 / 0.452 µM）所显示的活性与标准品非常相似。化合物4d，4f，4h和6d是有效的HCV RNA复制抑制剂，是进一步研究的良好候选药物。
• Amino-functionalized SBA-15 catalyzed one-step synthesis of 2-amino-5-cyano-4-hydroxy-6-aryl pyrimidines
  作者：M. Mirza-Aghayan、N. Mohammadian、M. Abolghasemi Malakshah、R. Boukherroub、A. A. Tarlani

  DOI：10.1007/s13738-012-0189-x

  日期：2013.6

  A simple and efficient approach towards one-step synthesis of 2-amino-5-cyano-4-hydroxy-6-aryl pyrimidines has been developed. It is based on three-component condensation of aliphatic, aromatic or heterocyclic aldehydes, ethyl cyanoacetate and guanidinium carbonate in the presence of amino-functionalized SBA-15 catalyst in ethanol. In this chemical process, the tautomeric interconversion of pyrimidine derivatives has been observed. This efficient technique has the advantage to give 2-amino-pyrimidine derivatives using a heterogeneous catalyst in high yields, to be completed in short reaction times and to offer a simple product isolation procedure.

  现已开发出一种简单高效的方法，可一步合成 2-氨基-5-氰基-4-羟基-6-芳基嘧啶。该方法基于脂肪族、芳香族或杂环醛、氰乙酸乙酯和碳酸胍在氨基官能化 SBA-15 催化剂存在下于乙醇中的三组分缩合。在这一化学过程中，观察到了嘧啶衍生物的同分异构体相互转化。这种高效的技术具有利用异相催化剂高产率生成 2-氨基嘧啶衍生物、反应时间短、产品分离过程简单等优点。
• A Novel and Efficient One-Pot Synthesis of 2-Aminopyrimidinones and Their Self-Assembly
  作者：Morteza Bararjanian、Saeed Balalaie、Frank Rominger、Sanaz Barouti

  DOI：10.1002/hlca.200900319

  日期：2010.4

  A three‐component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium carbonate affords 2‐amino‐4‐aryl‐1,6‐dihydro‐6‐oxopyrimidine‐5‐carbonitriles and the four‐component reaction of benzaldehyde derivatives, methyl cyanoacetate, and guanidinium hydrochloride in the presence of piperidine leads to piperidinium salts of pyrimidinones. X‐ray crystallography data confirm self‐assembly

  苯甲醛衍生物，氰基乙酸甲酯和碳酸胍的三组分反应得到2-氨基-4-芳基-1,6-二氢-6-氧嘧啶-5-腈和苯甲醛衍生物，氰基乙酸甲酯的四组分反应，在哌啶存在下，盐酸胍盐会生成嘧啶酮的哌啶鎓盐。X射线晶体学数据证实了这些化合物的自组装和氢键作用。
• A novel and efficient one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines and their anti-bacterial activity
  作者：M.B. Deshmukh、S.M. Salunkhe、D.R. Patil、P.V. Anbhule

  DOI：10.1016/j.ejmech.2008.10.018

  日期：2009.6

  The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria. The some of the compounds

  通过在碱性乙醇中芳族醛，氰基乙酸乙酯和盐酸胍的三组分缩合，已经开发出第一种简单有效的一步合成2-氨基-5-氰基-6-羟基-4-芳基嘧啶的方法。评估了合成化合物对革兰氏阳性和革兰氏阴性细菌的抗菌活性。一些化合物对被测细菌表现出优异的抑制作用。
• A spectral deciphering the perturbation of model transporter protein (HSA) by antibacterial pyrimidine derivative: Pharmacokinetic and biophysical insights
  作者：Vishwas D. Suryawanshi、Prashant V. Anbhule、Anil H. Gore、Shivajirao R. Patil、Govind B. Kolekar

  DOI：10.1016/j.jphotobiol.2012.09.010

  日期：2013.1

  Steady state fluorescence and UV-vis absorption spectroscopic techniques have been exploited to explore the binding interaction of a antibacterial pyrimidine derivative 2-amino-6-hydroxy-4-(4-hydroxy-phenyl)-pyrimidine-5-carbonitrile (AHHPPC) with the model transporter protein, human serum albumin (HSA) under the physiological conditions. It exhibits antibacterial activity against Escherichia coli and Staphylococcus aureus. Analysis of fluorescence quenching data of HSA at different temperatures using Stern-Volmer methods revealed the formation of AHHPPC-HSA complex with binding affinities of the order 10(4) M-1. The binding site number (n approximate to 1) and corresponding thermodynamic parameters (Delta G), (Delta H) and (Delta S) were calculated, indicated that binding reaction was endothermic and the hydrophobic interactions plays a major role in stabilizing the complex. The binding distance (r approximate to 3.13 nm) between donor (HSA) and acceptor (AHHPPC) was obtained according to FRET. Changes in the albumin secondary structure imparted by the compound was confirmed using synchronous fluorescence, electronic absorption, circular dichroism (CD) and three-dimensional (3D) fluorescence spectroscopy. All these experimental results clarified that AHHPPC could bind to HSA and be effectively transported and eliminated in body, which could be a useful guideline for further drug design. (C) 2012 Elsevier B.V. All rights reserved.