(+/-)-2-Amino-dodecansaeure-amid | 13880-54-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-2-Amino-dodecansaeure-amid
• 英文别名: (+/-)-2-amino-dodecanoic acid amide；2-Aminododecanamide
• CAS: 13880-54-1
• 化学式: C₁₂H₂₆N₂O
• 分子量: 214.351
• InChiKey: ANDNCZHWLXWDSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-2-Amino-dodecansaeure-amid 在 氢溴酸 作用下， 生成 (R)-2-氨基十二酸
  参考文献：
  名称：

  Enzymatic Resolution of Some Higher α-Amino Acids and Preparation of Optically Active α-Hydroxy Acids¹

  摘要：

  DOI：

  10.1021/ja01147a144
• 作为产物：
  描述：

  2-bromo-dodecanoic acid amide 在 氨 作用下， 60.0 ℃ 、2.45 MPa 条件下， 生成 (+/-)-2-Amino-dodecansaeure-amid
  参考文献：
  名称：

  Kempter,G.; Moser,G., Journal fur praktische Chemie (Leipzig 1954), 1966, vol. 34, p. 104 - 111

  摘要：

  DOI：

文献信息

• [EN] PRECISE SMALL MOLECULE RECOGNITION OF A TOXIC CUG RNA REPEAT EXPANSION<br/>[FR] RECONNAISSANCE PRÉCISE DE PETITES MOLÉCULES D'UNE EXPANSION DE RÉPÉTITION D'ARN CUG TOXIQUE
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2018098297A1

  公开（公告）日：2018-05-31

  Provided herein are compounds that bind to r(CUG)exp and methods of using the same for example to treat myotonic dystrophy, such as DM1.

  本文提供了与r(CUG)exp结合的化合物，以及使用这些化合物的方法，例如用于治疗肌阵挛性肌营养不良，如DM1。
• EP0410970A4
  申请人：——

  公开号：EP0410970A4

  公开（公告）日：1991-07-31
• REACTIVE HINDERED AMINE LIGHT STABILIZERS
  申请人：ATOCHEM NORTH AMERICA, INC.

  公开号：EP0410970A1

  公开（公告）日：1991-02-06
• THERMOPLASTIC MELT-MIXED COMPOSITION WITH AMINO ACID HEAT STABILIZER
  申请人：E. I. Du Pont de Nemours and Company

  公开号：EP2861660A1

  公开（公告）日：2015-04-22
• [EN] COMPOSITIONS OF POLYAMIDE AND IONOMER<br/>[FR] COMPOSITIONS À BASE DE POLYAMIDE ET DE IONOMÈRE
  申请人：DU PONT

  公开号：WO2013101961A1

  公开（公告）日：2013-07-04

  Disclosed is a shaped article and a method for preparing such an article, the article comprising a composition comprising (1) a polyamide having a melt viscosity from 200 Pas to 4000 Pas, measured at 250 °C and a shear rate of 12 sec"1 in an amount in the range of 35 to 70 weight % of the combination of (1) and (2); and (2) an ionomer composition in an amount in the range of 30 to 65 weight % of the combination of (1) and (2), wherein the ionomer composition comprises at least one neutralized acid copolymer, wherein the acid copolymer comprises copolymerized units of ethylene with (a) copolymerized units of an alpha-beta unsaturated monocarboxylic acid wherein the monocarboxylic acid is methacrylic acid or acrylic acid or a combination thereof; (b) optionally copolymerized units of an alpha-beta unsaturated dicarboxylic acid derivative selected from maleic anhydride and alkyl monoesters of maleic acid or fumaric acid, in the amount of 0 to 7 weight % of the copolymer; wherein the combination of (a) and (b) when present is from 7 to 21 weight % of the copolymer; (c) optionally copolymerized units of an alkyl acrylate or alkyl methacrylate comonomer, in the amount of 0 to 25 weight % of the copolymer; and wherein 50 mole % to 95 mole % of the total carboxylic acid groups in the copolymer are neutralized to salts comprising cations of zinc (Zn) and a second metal (M2) selected from Group 1 of the Periodic Table of the Elements, wherein Zn cations comprise 10 to 90 % mole equivalents and M2 cations comprise 90 to 10 % mole equivalents. The articles prepared from the compositions with mixed ion ionomers exhibit high stiffness, hardness and toughness, good scratch resistance, desirable low melt viscosity and high processability.