N,5-dimethyl-2-methylidene-4-[(4-methylphenyl)sulfonylamino]-N-phenylhexanamide | 1247767-93-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,5-dimethyl-2-methylidene-4-[(4-methylphenyl)sulfonylamino]-N-phenylhexanamide
• CAS: 1247767-93-6
• 化学式: C₂₂H₂₈N₂O₃S
• 分子量: 400.542
• InChiKey: PHPVJYUFSYEDFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  碘苯二乙酸 、 N,5-dimethyl-2-methylidene-4-[(4-methylphenyl)sulfonylamino]-N-phenylhexanamide 在 palladium diacetate 作用下， 以 溶剂黄146 为溶剂， 反应 20.0h， 以85%的产率得到(1-methyl-3-(3-methyl-2-(4-methylphenylsulfonamido)butyl)-2-oxoindolin-3-yl)methyl acetate
  参考文献：
  名称：

  Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles

  摘要：

  A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C H functionalization and C X bond formation was developed By simply changing the reaction conditions (solvent and catalyst), either 3,3'-disubstituted oxindole or spirooxindole was accessible from the same starting material.

  DOI：

  10.1021/ol101778c

文献信息

• Palladium-Catalyzed Carbo-Heterofunctionalization of Alkenes for the Synthesis of Oxindoles and Spirooxindoles
  作者：Stéphanie Jaegli、Jeremy Dufour、Hai-long Wei、Tiffany Piou、Xin-Hua Duan、Jean-Pierre Vors、Luc Neuville、Jieping Zhu

  DOI：10.1021/ol101778c

  日期：2010.10.15

  A palladium-catalyzed oxidative carbo-heterofunctionalization of aniline derivatives involving concomitant direct C H functionalization and C X bond formation was developed By simply changing the reaction conditions (solvent and catalyst), either 3,3'-disubstituted oxindole or spirooxindole was accessible from the same starting material.