2-methyl-5-(2-methyl-1,2-dihydroxypropyl)furan | 125923-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-methyl-5-(2-methyl-1,2-dihydroxypropyl)furan
• 英文别名: 2-methyl-1-(5-methylfuran-2-yl)propane-1,2-diol
• CAS: 125923-27-5
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: MOYNLSASCIWXBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  12.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  53.6
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-methyl-5-(2-methyl-1,2-dihydroxypropyl)furan 在 溴 、 对甲苯磺酸 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Synthetic studies towards paspalicine: Preliminary investigations, and the synthesis of 3′,4′,7′,7′a,9′,10′,11′,11′a-octahydro-4′,4′,7′a-trimethylspiro[1,3-dioxolane]-2,8′(6′H)-2′H-3′,5′a-epoxynaphth [2,1-b]oxepin-2′-one

  摘要：

  Preliminary investigations directed towards the synthesis of the indole-diterpene mould metabolite, paspalicine 1, are described. Following the preparation of the beta-pyrone ketal 7, which contains the characteristic functional group of paspalicine, the compound 25, which constitutes rings D-G of paspalicine with the correct relative stereochemistry, has been synthesised in eight steps from the monoketal 12 of the Wieland-Miescher ketone, in an overall yield of 8%.

  DOI：

  10.1016/s0040-4020(01)86569-8
• 作为产物：
  描述：

  5-甲基呋喃醛 在 四氧化锇 正丁基锂 、 N-甲基吗啉氧化物 作用下， 以 水 、 丙酮 、 叔丁醇 为溶剂， 反应 42.0h， 生成 2-methyl-5-(2-methyl-1,2-dihydroxypropyl)furan
  参考文献：
  名称：

  Synthetic studies towards paspalicine: Preliminary investigations, and the synthesis of 3′,4′,7′,7′a,9′,10′,11′,11′a-octahydro-4′,4′,7′a-trimethylspiro[1,3-dioxolane]-2,8′(6′H)-2′H-3′,5′a-epoxynaphth [2,1-b]oxepin-2′-one

  摘要：

  Preliminary investigations directed towards the synthesis of the indole-diterpene mould metabolite, paspalicine 1, are described. Following the preparation of the beta-pyrone ketal 7, which contains the characteristic functional group of paspalicine, the compound 25, which constitutes rings D-G of paspalicine with the correct relative stereochemistry, has been synthesised in eight steps from the monoketal 12 of the Wieland-Miescher ketone, in an overall yield of 8%.

  DOI：

  10.1016/s0040-4020(01)86569-8

文献信息

• Towards paspalicine : Synthesis of rings D-G
  作者：Amin Ali、J.Edwin Saxton

  DOI：10.1016/s0040-4039(00)99200-1

  日期：——
• ALI, AMIN;SAXTON, J. EDWIN, TETRAHEDRON LETT., 30,(1989) N4, C. 3197-3200
  作者：ALI, AMIN、SAXTON, J. EDWIN

  DOI：——

  日期：——
• ALI, AMIN;GUILE, SIMON D.;SAXTON, J. EDWIN;THORNTON-PETT, MARK, TETRAHEDRON, 47,(1991) N2, C. 6407-6426
  作者：ALI, AMIN、GUILE, SIMON D.、SAXTON, J. EDWIN、THORNTON-PETT, MARK

  DOI：——

  日期：——