10,11-epoxy-PGA2 | 42733-26-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10,11-epoxy-PGA2
• 英文别名: 10alpha,11alpha-oxido PGA2；(Z)-7-[(2R,3R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxo-6-oxabicyclo[3.1.0]hexan-3-yl]hept-5-enoic acid
• CAS: 42733-26-6
• 化学式: C₂₀H₃₀O₅
• 分子量: 350.455
• InChiKey: QGGPQDSQYUCJOO-MWGDGYRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  87.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  10,11-epoxy-PGA2 、 羟胺 生成 (Z)-7-[(1S,5R)-4-hydroxy-5-[(E,3S)-3-hydroxyoct-1-enyl]cyclopent-2-en-1-yl]hept-5-enoic acid
  参考文献：
  名称：

  ZINCHENKO, G. N.;SOMOV, K. V.;BEZUGLOV, V. V., SINTEZ I ISSLED. PROSTAGLANDINOV, MINSK,(1989) S. 79

  摘要：

  DOI：
• 作为产物：
  描述：

  前列腺素A2 生成 10,11-epoxy-PGA2
  参考文献：
  名称：

  ZINCHENKO, G. N.;SOMOV, K. V.;BEZUGLOV, V. V., SINTEZ I ISSLED. PROSTAGLANDINOV, MINSK,(1989) S. 79

  摘要：

  DOI：

文献信息

• (5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9.13-trien-1-oic acid and esters
  申请人：G. D. Searle & Co.

  公开号：US03954844A1

  公开（公告）日：1976-05-04

  Preparation and the antispasmodic utility of (5Z,13E,15S)-15-hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid and esters are disclosed.

  本文披露了(5Z,13E,15S)-15-羟基-11-氧代-前列腺-5,9,13-三烯-1-酸及其酯类的制备和抗痉挛作用。
• 1,3-Dinitrates of cyclooxygenase metabolites of endocannabinoid 2-arachidonoylglycerol. Synthesis and properties
  作者：I. V. Serkov、V. V. Bezuglov

  DOI：10.1134/s1068162009020113

  日期：2009.3

  The 1,3-Dinitrates of glycerol esters of natural prostaglandins that are the cyclooxygenase metabolites of 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors, were synthesized for the first time. Four methods of synthesis of these esters were developed via the activation of a carboxyl group and their chemical and pharmacological properties were investigated. The esters exhibit a more selective pharmacological spectrum of activities in comparison with the corresponding natural prostaglandins: some types of myotropic activity were enhanced, while others were loosened. 1,3-dinitroglycerol esters act as vasodilators, whereas the majority of natural prostaglandins act as vasoconstrictors. The observed changes result from the introduction of an NO-releasing fragment into prostaglandin molecule.
• ZINCHENKO, G. N.;SOMOV, K. V.;BEZUGLOV, V. V., SINTEZ I ISSLED. PROSTAGLANDINOV, MINSK,(1989) S. 79
  作者：ZINCHENKO, G. N.、SOMOV, K. V.、BEZUGLOV, V. V.

  DOI：——

  日期：——
• US3954844A
  申请人：——

  公开号：US3954844A

  公开（公告）日：1976-05-04
• US4171312A
  申请人：——

  公开号：US4171312A

  公开（公告）日：1979-10-16