2-[[(2-羟基苯基)甲基]氨基]乙酰胺 | 57938-79-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[[(2-羟基苯基)甲基]氨基]乙酰胺
• 英文名称: N-(2-Hydroxybenzyl)glycinamid
• 英文别名: N-(2-hydroxybenzyl)-glycinamide；2-{[(2-hydroxyphenyl)methyl]amino}acetamide；2-[[(2-Hydroxyphenyl)methyl]amino]acetamide；2-[(2-hydroxyphenyl)methylamino]acetamide
• CAS: 57938-79-1
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: PQXNDCCYQCMSTJ-UHFFFAOYSA-N

物化性质

• 熔点：
  117-119 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• 沸点：
  394.8±27.0 °C(Predicted)
• 密度：
  1.227±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 2-[[(2-羟基苯基)甲基]氨基]乙酰胺 以 乙醇 、 水 为溶剂， 以79%的产率得到[Cu(N-(2-hydroxybenzyl)-glycinamide-H)2(NO3)2]
  参考文献：
  名称：

  Syntheses, structures and properties of copper(II) complexes containing N-(2-hydroxybenzyl)-amino amide ligands

  摘要：

  Four copper(II) complexes containing the reduced Schiff base ligands, namely, N-(2-hydroxybenzyl)-glycinamide (Hsglym) and N-(2-hydroxybenzyl)-L-alaninamide (Hsalam) have been synthesized and characterized. The crystal structures of [Cu-2(sglym)(2)Cl-2] (1), [Cu-2(salam)(2)(NO3)(2)]center dot H2O(3), [Cu-2(salam)(2)(NO3)(H2O)](NO3)center dot 1.5H(2)O (4), [Cu-2(salam)(2)](ClO4)(2)center dot 2H(2)O (5) show that the Cu(II) atoms are bridged by two phenolato oxygen atoms in the dimers. The sglym ligand bonded to Cu(II) in facial manner while salam ligand prefers to bind to Cu(II) in meridonal geometry. Variable temperature magnetic studies of 3 showed it is antiferromagnetic. These Cu(II) complexes and [Cu-2(sglym)(2)(NO3)(2)](2), exhibit very small catecholase activity as compared to the corresponding complexes containing acid functional groups. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.01.006
• 作为产物：
  描述：

  N-[(2-羟基苯基)甲基]甘氨酸乙酯 在 氨 作用下， 以 甲醇 为溶剂， 生成 2-[[(2-羟基苯基)甲基]氨基]乙酰胺
  参考文献：
  名称：

  Bernardi; Coda; Nicolella, Arzneimittel-Forschung/Drug Research, 1979, vol. 29, # 9, p. 1412 - 1416

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS DERIVED FROM 1 -ETHYL-4,5-DIAMINO-PYRAZOLE AND THEIR USE FOR OXIDATIVE DYEING OF KERATIN FIBRES<br/>[FR] COMPOSÉS DÉRIVÉS DE 1 -ÉTHYL-4,5-DIAMINO-PYRAZOLE ET LEUR UTILISATION DANS LA TEINTURE OXYDANTE DE FIBRES KÉRATINIQUES
  申请人：KEMON S P A

  公开号：WO2008047210A2

  公开（公告）日：2008-04-24

  [EN] The invention concerns new compounds derived from 1-ethyl-4,5-diamino- pyrazole of formula (I) as dye precursors to be used in compositions with coupling agents for oxidative dyeing of keratin fibres, preferably hair.
  [FR] La présente invention concerne de nouveaux composés dérivés de 1-éthyl-4,5-diamino- pyrazole de formule (I) utiles comme précurseurs de colorant destinés à être utilisés dans des compositions avec des agents de couplage pour la teinture oxydante de fibres kératiniques, notamment les cheveux.
• Bernardi; Coda; Nicolella, Arzneimittel-Forschung/Drug Research, 1979, vol. 29, # 9, p. 1412 - 1416
  作者：Bernardi、Coda、Nicolella、Vicario、Gioia、Minghetti、Vigevani、Arcamone

  DOI：——

  日期：——
• Syntheses, structures and properties of copper(II) complexes containing N-(2-hydroxybenzyl)-amino amide ligands
  作者：Xiaobai Wang、Jun Ding、Jagadese J. Vittal

  DOI：10.1016/j.ica.2006.01.006

  日期：2006.8

  Four copper(II) complexes containing the reduced Schiff base ligands, namely, N-(2-hydroxybenzyl)-glycinamide (Hsglym) and N-(2-hydroxybenzyl)-L-alaninamide (Hsalam) have been synthesized and characterized. The crystal structures of [Cu-2(sglym)(2)Cl-2] (1), [Cu-2(salam)(2)(NO3)(2)]center dot H2O(3), [Cu-2(salam)(2)(NO3)(H2O)](NO3)center dot 1.5H(2)O (4), [Cu-2(salam)(2)](ClO4)(2)center dot 2H(2)O (5) show that the Cu(II) atoms are bridged by two phenolato oxygen atoms in the dimers. The sglym ligand bonded to Cu(II) in facial manner while salam ligand prefers to bind to Cu(II) in meridonal geometry. Variable temperature magnetic studies of 3 showed it is antiferromagnetic. These Cu(II) complexes and [Cu-2(sglym)(2)(NO3)(2)](2), exhibit very small catecholase activity as compared to the corresponding complexes containing acid functional groups. (c) 2006 Elsevier B.V. All rights reserved.