2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-二甲基-3-磺基氧基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酰]氨基]乙酸 | 15324-64-8

• 物质功能分类: 生物化工 - 氨基酸及其衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-二甲基-3-磺基氧基-2,3,4,5,6,7,8,9,11,12,14,15,16,17-十四氢-1H-环戊二烯并[a]菲-17-基]戊酰]氨基]乙酸
• 英文名称: Sulfoglycolithocholic acid
• 英文别名: 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-sulfooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid
• CAS: 15324-64-8
• 化学式: C₂₆H₄₃NO₇S
• 分子量: 513.7
• InChiKey: FHXBAFXQVZOILS-OETIFKLTSA-N

物化性质

• 密度：
  1.26±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 碰撞截面：
  215.6 Ų [M-H]- [CCS Type: DT, Method: single field calibrated]

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile
  申请人：One Way Liver Genomics, S.L.

  公开号：EP2309276A1

  公开（公告）日：2011-04-13

  The invention relates to methods for the diagnosis of non-alcoholic steatosis (NASH). The method relies on the determination of certain metabolic markers in a biological sample of the patient which are up- or down-regulated in the NASH patients vs. patients with a simple fatty liver (steatosis).

  本发明涉及诊断非酒精性脂肪肝（NASH）的方法。该方法依赖于测定患者生物样本中的某些代谢标记物，这些标记物在非酒精性脂肪肝患者与单纯脂肪肝（脂肪变性）患者中上调或下调。
• Graphite electrode comprising electrochemically reduced graphene oxide and methods thereof
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US10156539B2

  公开（公告）日：2018-12-18

  A modified graphite electrode comprising a coating of electrochemically reduced graphene oxide. The modified graphite electrode may be employed in detecting of uric acid. A sensing device comprising the modified graphite electrode and a method of making the modified graphite electrode are described herein.

  一种改性石墨电极，包括一层电化学还原氧化石墨烯涂层。改性石墨电极可用于检测尿酸。本文描述了一种包含改性石墨电极的传感装置和一种制造改性石墨电极的方法。
• Detection of serum methionine and glucose by graphite pencil electrode
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11474067B2

  公开（公告）日：2022-10-18

  A method of using a graphite electrode to measure a concentration of glucose or methionine from a biological sample is described. A mechanical pencil lead may be used, as the graphite electrode, and the biological sample may come from a patient's serum. The glucose or methionine may produce a peak current response within a range of 0.4-0.8 V when the sample is subjected to linear scan voltammetry.

  描述了一种使用石墨电极测量生物样本中葡萄糖或蛋氨酸浓度的方法。可以使用机械铅笔芯作为石墨电极，生物样本可以来自病人的血清。在对样品进行线性扫描伏安法测量时，葡萄糖或蛋氨酸可在 0.4-0.8 V 范围内产生峰值电流响应。
• METHOD OF TACROLIMUS EXTRACTION AND QUANTIFICATION USING AQUEOUS DETERGENTS
  申请人：ABBOTT LABORATORIES

  公开号：EP1949100A1

  公开（公告）日：2008-07-30
• METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF
  申请人：Georgia Tech Research Corporation

  公开号：EP2279417A1

  公开（公告）日：2011-02-02